The overall goals of the Administrative Core are to provide general scientific, programmatic and fiscal leadership, facilitate lines of communication between the different researchers involved in the Program Project, maintain coherence of the organization in the context of the overall objectives and long-range goals, and ensure that the resources that result from the Program will benefit the scientific community. In the context of the above, the tasks of this core include the effective coordination of activities in the 5 research projects and the Animal and Pathology Core towards unraveling the role of genome maintenance in aging and longevity, the selection and breeding of the jointly used mouse models, the mobilization of new technology and tools that can help us accomplishing our tasks quicker and more efficiently, to maintain and update our Mouse Database for effective utilization by researchers in this PPG, and to provide the scientific community access to the PPG's resources, information and technologies through the internet.

Public Health Relevance

The wide diversity of researchers at different locations, sharing the same resources, requires a strong centralizing force capable of synthesizing the new concepts and results emerging from this program project and make its resources available to the scientific community. It is this requirement that is central to the Administrative Core of this program project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG017242-16
Application #
8437198
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
16
Fiscal Year
2013
Total Cost
$120,109
Indirect Cost
$47,754
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Lau, Cia-Hin; Suh, Yousin (2018) In vivo epigenome editing and transcriptional modulation using CRISPR technology. Transgenic Res 27:489-509
Wiley, Christopher D; Schaum, Nicholas; Alimirah, Fatouma et al. (2018) Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. Sci Rep 8:2410
Quispe-Tintaya, Wilber; Lee, Moonsook; Dong, Xiao et al. (2018) Bleomycin-induced genome structural variations in normal, non-tumor cells. Sci Rep 8:16523
HĂ©bert, Jean M; Vijg, Jan (2018) Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends Neurosci 41:267-279
Yu, Bo; Dong, Xiao; Gravina, Silvia et al. (2017) Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation. Stem Cell Reports 9:397-407
Vijg, Jan; Dong, Xiao; Zhang, Lei (2017) A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden. Exp Biol Med (Maywood) 242:1318-1324
Ogrodnik, Mikolaj; Miwa, Satomi; Tchkonia, Tamar et al. (2017) Cellular senescence drives age-dependent hepatic steatosis. Nat Commun 8:15691
Dong, Xiao; Zhang, Lei; Milholland, Brandon et al. (2017) Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nat Methods 14:491-493
Olivieri, Fabiola; Capri, Miriam; Bonafè, Massimiliano et al. (2017) Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging. Mech Ageing Dev 165:162-170
Perrott, Kevin M; Wiley, Christopher D; Desprez, Pierre-Yves et al. (2017) Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience 39:161-173

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