(from the application): More and more people in this country live at least part of their lives alone. Teenagers grow up with parents off at work, and often substitute computers or the Internet for the companionship of peers. Increasing divorce rates bring isolation to many in the middle years, and the death of a spouse is an expected fact of later life. The result is social isolation and, presumably, loneliness for many. Epidemiological and prospective studies have identified social isolation as a major risk factor for psychological disturbances and for broad-based morbidity and mortality. Most studies have focused on the amount of those in the social network rather than the emotional experience of loneliness resulting from personal relationships. Accordingly, the behavioral, psychological, and biological mechanisms responsible for the epidemiological relationship between social isolation and health are not well understood. We seek to examine four specific social-psychophysiological pathways in a 5-year longitudinal study of a representative Community sample of 230 older adults, 50-64 years of age.
Aim 1 of Project 1 is to determine predictors of loneliness cross-sectionally in Year 1 and to examine the temporal stability of loneliness in older adults over a 5-year period.
Aim 2 is to follow-up our prior research linking loneliness to relatively high total peripheral resistance and blood pressure and disrupted sleep; and to examine whether loneliness is related to elevated hypothalamic pituitary adrenocortical (HPA) activation and poorer health behaviors. The specificity of these associations will be determined by statistically controlling for correlated variables (e.g., hostility, depression, attachment style, anxiety). Finally, as recent reviews of the literature have noted, """"""""it is not clear whether the differences that have been found between lonely people and those not lonely reflect differences in their behavior or in their perceptions"""""""" (Berscheid & Reis, 1998, p. 244).
Aim 3, therefore, is to examine whether lonely and nonlonely individuals differ in their exposure to stressors (differential exposure) or their reactivity to stressors (differential reactivity), and/or their recovery from stressors (differential recovery).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG018911-01A1
Application #
6406061
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2001-07-01
Project End
2006-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cacioppo, John T; Cacioppo, Stephanie (2018) The Population-Based Longitudinal Chicago Health, Aging, and Social Relations Study (CHASRS): Study Description and Predictors of Attrition in Older Adults. Arch Sci Psychol 6:21-31
Cole, Steven W; Capitanio, John P; Chun, Katie et al. (2015) Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. Proc Natl Acad Sci U S A 112:15142-7
Luhmann, Maike; Hawkley, Louise C; Cacioppo, John T (2014) Thinking About One's Subjective Well-Being: Average Trends and Individual Differences. J Happiness Stud 15:757-781
Cacioppo, John T; Cacioppo, Stephanie; Boomsma, Dorret I (2014) Evolutionary mechanisms for loneliness. Cogn Emot 28:3-21
Caruso, M J; McClintock, M K; Cavigelli, S A (2014) Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats. Horm Behav 66:517-24
Cacioppo, John T; Cacioppo, Stephanie (2014) Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. Soc Personal Psychol Compass 8:58-72
Powell, Nicole D; Sloan, Erica K; Bailey, Michael T et al. (2013) Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via ?-adrenergic induction of myelopoiesis. Proc Natl Acad Sci U S A 110:16574-9
Cacioppo, Stephanie; Couto, Blas; Bolmont, Mylene et al. (2013) Selective decision-making deficit in love following damage to the anterior insula. Curr Trends Neurol 7:15-19
VanderWeele, Tyler J; Hawkley, Louise C; Cacioppo, John T (2012) On the reciprocal association between loneliness and subjective well-being. Am J Epidemiol 176:777-84
Cacioppo, John T; Cacioppo, Stephanie (2012) The Phenotype of Loneliness. Eur J Dev Psychol 9:446-452

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