The primary goals of Project 1 are (1) to recruit a new national probability sample of 2,100 respondents (aged 25-54) as well as a new stratified sample of 500 African Americans from Milwaukee, Wl (also aged 25-54), and (2) carry out the 2nd longitudinal follow-up ofthe existing samples (MIDUS III). All respondents will complete the same set of assessments - a phone interview (or personal interview in Milwaukee) and selfadministered questionnaires - that were obtained at MIDUS II. A key reason for refreshing (augmenting) the MIDUS samples is to allow for investigation of period effects ofthe economic recession by comparing sameaged adults from the MIDUS I (pre-recession) sample assessed in 1995/96 with the refresher (postrecession) sample assessed in 2011/12 on a multitude of indicators of economic adversity, mental and physical health, and psychosocial moderators. The expanded sample sizes will also facilitate cross-project analyses focused on the interplay of sociodemographic, psychosocial, and biological influences on the health of mid- and later-life adults. The second primary objective, that of launching the 3rd wave of assessments on the existing MIDUS samples (? 5,500 respondents), will allow for more precise and reliable estimates of change in key variables as well as strengthen opportunities for testing psychosocial factors (negative and positive) as moderators or mediators of age-related changes in health. Our revision offers extensive evidence of the many lines of research that have been pursued with MIDUS survey data (255 publications to date, 59 of which are based on MIDUS II data), all of which will be advanced by the planned expansion of the sample and its related focus on the economic recession as well as by carrying out the next longitudinal follow-up of the existing sample. Project 1 also serves as the hub from which all other projects emanate, making its sample recruitment and data collection essential for moving forward all components ofthe MIDUS enterprise. Overall, our planned additions will allow MIDUS to become a major forum for investigating how the economic recession is affecting the health of young and midlife adults, while also move forward the next phase of assessments 9-10 years later (adhering to the interval between MIDUS I and MIDUS II) with the existing sample. In the longer term, our proposed plans lay the groundwork for longitudinal tracking of parallel samples of adults (aged 25-54) from different birth cohorts whose biopsychosocial aging is unfolding in the context of major economic upheaval - hence, our emphasis, akin to Elder's classic work, on adults of the great recession.

Public Health Relevance

The societal significance ofthe proposed research is that MIDUS will advance knowledge of external life challenges, including economic adversity, along with intervening psychological outlooks and social relationships are consequential for later life health (morbidity and mortality). Because such psychosocial factors can serve as protective resources and, in addition, are modifiable, they serve as important targets for prevention and positive health promotion in the U.S. population, particulariy in difficult economic times.

National Institute of Health (NIH)
National Institute on Aging (NIA)
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Special Emphasis Panel (ZAG1-ZIJ-1 (J1))
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University of Wisconsin Madison
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Stepanikova, Irena; Bateman, Lori Brand; Oates, Gabriela R (2017) Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. Am J Prev Med 52:S63-S76
Ransome, Yusuf; Slopen, Natalie; Karlsson, Oskar et al. (2017) The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample. Brain Behav Immun 66:313-321
Barrett, Anne E; Toothman, Erica L (2017) Multiple ""Old Ages"": The Influence of Social Context on Women's Aging Anxiety. J Gerontol B Psychol Sci Soc Sci :
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Yoo, Jiah; Miyamoto, Yuri; Rigotti, Attilio et al. (2017) Linking Positive Affect to Blood Lipids: A Cultural Perspective. Psychol Sci 28:1468-1477
Tsenkova, Vera K (2017) Leisure-time, occupational, household physical activity and insulin resistance (HOMAIR) in the Midlife in the United States (MIDUS) national study of adults. Prev Med Rep 5:224-227
Priest, Jacob B (2017) Examining Differentiation of Self as a Mediator in the Biobehavioral Family Model. J Marital Fam Ther :
Boylan, Jennifer Morozink; Tsenkova, Vera K; Miyamoto, Yuri et al. (2017) Psychological resources and glucoregulation in Japanese adults: Findings from MIDJA. Health Psychol 36:449-457
Vittengl, J R (2017) Who pays the price for high neuroticism? Moderators of longitudinal risks for depression and anxiety. Psychol Med 47:1794-1805
Boylan, Jennifer Morozink; Robert, Stephanie A (2017) Neighborhood SES is particularly important to the cardiovascular health of low SES individuals. Soc Sci Med 188:60-68

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