The purpose of Project 4 is to collect comprehensive biological assessments, paralleling those obtained on the existing MIDUS II sample, on a new refresher sample of 800 individuals (aged 25-54) recruited from the Project 1 refresher samples. Approximately 650 respondents will be from the national probability sample (N = 2,100), while 150 will be from the new African American sample in Milwaukee, Wl (N=500). These additions will increase the size of the existing biomarker sample (N = 1,255) by about 65% (62% for RDD, 75% for Milwaukee). Participants will travel to one of three clinical research centers (University of California, Los Angeles;University of Wisconsin, Madison;Georgetown University, Washington, DC) for an overnight stay. Data to will be collected across four biological systems: neuroendocrine, inflammatory, cardiovascular, and musculoskeletal. A laboratory study will include measures of blood pressure, heart-rate variability, respiratory rate, and salivary cortisol before, during and after various challenges (cognitive and orthostatic). In response to prior concerns about innovation, we have added an expanded cytokine panel, metabolic profiling, and insulin-like growth factor (IGF-1), all of which will be assessed in the new refresher biomarker sample as well as the MIDUS 11 biomarker sample (using stored specimens). Key rationales for augmenting the biomarker sample are to: (a) establish baseline biomarkers for young adults aged 25-34 who are missing from the current sample because biomarkers were added at the 2 wave of MIDUS;(b) afford tests of period effects, linked to the economic recession, in biomarker levels (e.g., cortisol, catecholamines, inflammation, blood pressure, waist-hip ratio;glucose and lipid regulation);and (c) expand the size of the biomarker sample (Refresher + MIDUS II) needed for cross-project analyses investigating the interplay between sociodemographic and psychosocial factors in predicting biomarker levels. Many hypotheses will be pursued, but overarching predictions are that major economic upheaval can be consequential for biological regulation, with such effects likely moderated by sociodemographic status variables (e.g., income, education) as well as by psychosocial factors (e.g., quality of social relationships, well-being). Because this P01 will also include longitudinal follow-up for survey (Project 1) and cognitive (Project 3) assessments of the existing sample, a further aim will be to begin analyses that investigate biological systems (assessed at MIDUS II) as mediators of relationships between prior psychosocial factors (MIDUS I &II) and unfolding profiles of morbidity and mortality (MIDUS III).

Public Health Relevance

The societal significance of the proposed research is that MIDUS will advance knowledge of how sociodemographic and psychosocial factors in early and middle adulthood contribute to, or protect against, risk in multiple biological systems that influence later life morbidity and mortality. Because many psychosocial factors are modifiable, they serve as important targets for prevention and positive health promotion in the U.S. population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG020166-09
Application #
8491991
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$1,806,475
Indirect Cost
$278,610
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kong, Jooyoung (2018) Effect of Caring for an Abusive Parent on Mental Health: The Mediating Role of Self-Esteem. Gerontologist 58:456-466
Grupe, Daniel W; Schaefer, Stacey M; Lapate, Regina C et al. (2018) Behavioral and neural indices of affective coloring for neutral social stimuli. Soc Cogn Affect Neurosci 13:310-320
Serrat, Rodrigo; Villar, Feliciano; Pratt, Michael W et al. (2018) On the quality of adjustment to retirement: The longitudinal role of personality traits and generativity. J Pers 86:435-449
Wardecker, Britney M; Matsick, Jes L; Graham-Engeland, Jennifer E et al. (2018) Life Satisfaction Across Adulthood in Bisexual Men and Women: Findings from the Midlife in the United States (MIDUS) Study. Arch Sex Behav :
Drewelies, Johanna; Agrigoroaei, Stefan; Lachman, Margie E et al. (2018) Age variations in cohort differences in the United States: Older adults report fewer constraints nowadays than those 18 years ago, but mastery beliefs are diminished among younger adults. Dev Psychol 54:1408-1425
van Reekum, Carien M; Schaefer, Stacey M; Lapate, Regina C et al. (2018) Aging is associated with a prefrontal lateral-medial shift during picture-induced negative affect. Soc Cogn Affect Neurosci 13:156-163
Kitayama, Shinobu; Park, Jiyoung; Miyamoto, Yuri et al. (2018) Behavioral Adjustment Moderates the Link Between Neuroticism and Biological Health Risk: A U.S.-Japan Comparison Study. Pers Soc Psychol Bull 44:809-822
Wolf, Tovah; Tsenkova, Vera; Ryff, Carol D et al. (2018) Neural, Hormonal, and Cognitive Correlates of Metabolic Dysfunction and Emotional Reactivity. Psychosom Med 80:452-459
Radler, Barry T; Rigotti, Attilio; Ryff, Carol D (2018) Persistently high psychological well-being predicts better HDL cholesterol and triglyceride levels: findings from the midlife in the U.S. (MIDUS) longitudinal study. Lipids Health Dis 17:1
Song, Jieun; Mailick, Marsha R; Greenberg, Jan S (2018) Health of parents of individuals with developmental disorders or mental health problems: Impacts of stigma. Soc Sci Med 217:152-158

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