Declining immune function of older adults Is a hallmarl

Public Health Relevance

Relevance: While it is well recognized that current split-virus vacciines provide limited protection in older people, strategies that completely rely on antibody titers have failed to develop more effective vaccines. A mechanistic approach to vaccine development and a greater understanding of how to improve aged memory T cell responses to influenza is needed;an adjuvanted vaccine formulation holds the greatest promise for better proetecion in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG021600-08A1
Application #
8261477
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1 (02))
Project Start
Project End
2013-05-31
Budget Start
2012-06-15
Budget End
2013-05-31
Support Year
8
Fiscal Year
2012
Total Cost
$280,349
Indirect Cost
Name
Trudeau Institute, Inc.
Department
Type
DUNS #
020658969
City
Saranac Lake
State
NY
Country
United States
Zip Code
12983
Zhang, Wenliang; Brahmakshatriya, Vinayak; Swain, Susan L (2014) CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. Exp Gerontol 54:67-70
McKinstry, K Kai; Dutton, Richard W; Swain, Susan L et al. (2013) Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful. Arch Immunol Ther Exp (Warsz) 61:341-53
Lefebvre, Julie S; Haynes, Laura (2013) Vaccine strategies to enhance immune responses in the aged. Curr Opin Immunol 25:523-8
Haynes, Laura; Swain, Susan L (2012) Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol :
Blackman, Marcia A; Woodland, David L (2011) The narrowing of the CD8 T cell repertoire in old age. Curr Opin Immunol 23:537-42
Jones, Stephen C; Brahmakshatriya, Vinayak; Huston, Gail et al. (2010) TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol 185:6783-94
Kohlmeier, Jacob E; Connor, Lisa M; Roberts, Alan D et al. (2010) Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol 185:3456-62
Takamura, Shiki; Roberts, Alan D; Jelley-Gibbs, Dawn M et al. (2010) The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen. J Exp Med 207:1153-60
Tsukamoto, Hirotake; Huston, Gail E; Dibble, John et al. (2010) Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol 185:4535-44
Maue, Alexander C; Eaton, Sheri M; Lanthier, Paula A et al. (2009) Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol 182:6129-35

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