Declining immune function of older adults Is a hallmarl

Public Health Relevance

Relevance: While it is well recognized that current split-virus vacciines provide limited protection in older people, strategies that completely rely on antibody titers have failed to develop more effective vaccines. A mechanistic approach to vaccine development and a greater understanding of how to improve aged memory T cell responses to influenza is needed;an adjuvanted vaccine formulation holds the greatest promise for better proetecion in this population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-1 (02))
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Trudeau Institute, Inc.
Saranac Lake
United States
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