Abstract

Declining immune function of older adults Is a hallmarl

Public Health Relevance

Relevance: While it is well recognized that current split-virus vacciines provide limited protection in older people, strategies that completely rely on antibody titers have failed to develop more effective vaccines. A mechanistic approach to vaccine development and a greater understanding of how to improve aged memory T cell responses to influenza is needed;an adjuvanted vaccine formulation holds the greatest promise for better proetecion in this population.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
7P01AG021600-09
Application #
8485482
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
9
Fiscal Year
2013
Total Cost
$334,110
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Lorenzo, Erica C; Bartley, Jenna M; Haynes, Laura (2018) The impact of aging on CD4+ T cell responses to influenza infection. Biogerontology 19:437-446
Parham, Kourosh; Kuchel, George A; McElhaney, Janet E et al. (2018) A Relationship Between Blood Levels of Otolin-1 and Vitamin D. Otol Neurotol 39:e269-e273
Lanzer, Kathleen G; Cookenham, Tres; Reiley, William W et al. (2018) Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection. Immun Ageing 15:17
Kuchel, George A (2018) Frailty and Resilience as Outcome Measures in Clinical Trials and Geriatric Care: Are We Getting Any Closer? J Am Geriatr Soc 66:1451-1454
Brahmakshatriya, Vinayak; Kuang, Yi; Devarajan, Priyadharshini et al. (2017) IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. J Immunol 198:2819-2833
Merani, Shahzma; Pawelec, Graham; Kuchel, George A et al. (2017) Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection. Front Immunol 8:784
Bartley, Jenna M; Zhou, Xin; Kuchel, George A et al. (2017) Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses. Front Immunol 8:1164
Swain, Susan L; Kugler-Umana, Olivia; Kuang, Yi et al. (2017) The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age. Cell Immunol 321:52-60
Tabtabai, Ryan; Haynes, Laura; Kuchel, George A et al. (2017) Age-Related Increase in Blood Levels of Otolin-1 in Humans. Otol Neurotol 38:865-869
Masters, A R; Haynes, L; Su, D-M et al. (2017) Immune senescence: significance of the stromal microenvironment. Clin Exp Immunol 187:6-15

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