The IMS Core will continue to coordinate efficient and consistent utilization of neuroimaging and nonneuroimaging measures and provide statistical support across projects and cores for this program project grant (PPG). The IMS Core provides methods and staff support that is readily accessible to investigators and is a technical core for image data acquisition, processing, analysis, and evaluation. The Core also provides data management support and is an integral component of each project and is linked to all projects and Cores. The IMS core will also continue to: 1) provide valid and standardized neuroimaging methods for PET and MR data acquisition with timely analysis and evaluation;2) provide data management that ensures timely and secure data entry, storage, retrieval, quality control (QC) checks, and archiving;3) provide statistical consultation;and 4) serve as a methodology training resource. The IMS Core aims for the PPG renewal period are:
Aim 1. To acquire and manage neuroimaging data used to assess amyloid deposition and metabolic rate (via PET) and tissue volume, morphometric differences, white matter lesions, and blood flow (via MRI) Aim 2. To provide robust structural and functional neuroimaging measures for primary (and exploratory) aims Aim 3. To provide tools that can be used to determine temporal and spatial characteristics of neuroimaging measures across time and relative to non-imaging covariates and/or post-mortem correlates Aim 4. To provide imaging and statistical consultation to investigators to achieve the project aims Aim 5. To provide training to students and faculty in amyloid imaging and related neuroimaging methodology

Public Health Relevance

;The IMS Core activities have helped to build a strong PiB PET research infrastructure that allows for efficient pooling of resources and experience that is needed to further PPG research goals and support further development, refinement, and validation of tools for collaborative research efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG025204-09
Application #
8572487
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
9
Fiscal Year
2013
Total Cost
$243,230
Indirect Cost
$83,522
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Mizukami, Katsuyoshi; Akatsu, Hiroyasu; Abrahamson, Eric E et al. (2016) Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology 36:135-45
Ikonomovic, Milos D; Abrahamson, Eric E; Price, Julie C et al. (2016) [F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding. Ann Neurol 80:307-8
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Klunk, William E; Koeppe, Robert A; Price, Julie C et al. (2015) The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 11:1-15.e1-4
Marquié, Marta; Normandin, Marc D; Vanderburg, Charles R et al. (2015) Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol 78:787-800
Nichols, Noah; Bras, Jose M; Hernandez, Dena G et al. (2015) EIF4G1 mutations do not cause Parkinson's disease. Neurobiol Aging 36:2444.e1-4
Goodheart, A E; Tamburo, E; Minhas, D et al. (2015) Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities. Neuroimage Clin 9:479-83
Yau, Wai-Ying Wendy; Tudorascu, Dana L; McDade, Eric M et al. (2015) Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study. Lancet Neurol 14:804-13
Chen, Yin J; Rosario, Bedda L; Mowrey, Wenzhu et al. (2015) Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET. J Nucl Med 56:1199-205
Mountz, James M; Laymon, Charles M; Cohen, Ann D et al. (2015) Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects. Neuroimage Clin 9:592-8

Showing the most recent 10 out of 88 publications