The Administrative Core provides central support to maintain optimal functioning of the Program Project. Its goals are two-fold;first, to maximize efficient use of investigator time by tracking expenses and preparing budgets, facilitating preparation of manuscripts and correspondence to the NIA regarding the PPG (example, progress reports and financial summaries), ordering and receiving supplies, arranging equipment repair and compliance with institutional requirements (filing of protocols required for use of vertebrate animals, and adherence to environmental health and safety/biohazard and radiation guidelines), organizing meetings of the executive committee (Project and Core Leaders), meetings of the entire group (including presentations from the Columbia group and outside speakers), meetings of the Internal Advisory Board, and the External Advisory Board;and second, to provide a cohesive and well-structured mechanism for tracking mice, rats and data management;and strong biostatistical support. The Core will be administered by Dr. Schmidt and Ms. Evan, who have worked together and the other investigators extensively. Mr. Kevin McGhee serves as the laboratory manager to facilitate compliance, equipment and ordering responsibilities. All Projects (1-3) and Cores B&C will employ Core A extensively during all five years of the Program Project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
7P01AG026467-04
Application #
8235875
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
4
Fiscal Year
2011
Total Cost
$148,587
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Thiagarajan, Devi; Vedantham, Srinivasan; Ananthakrishnan, Radha et al. (2016) Mechanisms of transcription factor acetylation and consequences in hearts. Biochim Biophys Acta 1862:2221-2231
Thiagarajan, Devi; Ananthakrishnan, Radha; Zhang, Jinghua et al. (2016) Aldose Reductase Acts as a Selective Derepressor of PPAR? and the Retinoic Acid Receptor. Cell Rep 15:181-96
Zirpoli, Hylde; Abdillahi, Mariane; Quadri, Nosirudeen et al. (2015) Acute administration of n-3 rich triglyceride emulsions provides cardioprotection in murine models after ischemia-reperfusion. PLoS One 10:e0116274
Schmidt, Ann Marie (2015) Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease. Vascul Pharmacol 72:1-8
Gao, Minghui; Monian, Prashant; Quadri, Nosirudeen et al. (2015) Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell 59:298-308
Schmidt, Ann Marie (2015) The growing problem of obesity: mechanisms, consequences, and therapeutic approaches. Arterioscler Thromb Vasc Biol 35:e19-23
Schmidt, Ann Marie (2014) Recent highlights of ATVB: diabetes mellitus. Arterioscler Thromb Vasc Biol 34:954-8
Vedantham, Srinivasan; Thiagarajan, Devi; Ananthakrishnan, Radha et al. (2014) Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals. Diabetes 63:761-74
Schmidt, Ann Marie (2014) Skin autofluorescence, 5-year mortality, and cardiovascular events in peripheral arterial disease: all that glitters is surely not gold. Arterioscler Thromb Vasc Biol 34:697-9
Bao, Li; Taskin, Eylem; Foster, Monique et al. (2013) Alterations in ventricular K(ATP) channel properties during aging. Aging Cell 12:167-76

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