The Clinical Core will provide Projects 3 & 4 with recruitment and phenotypic characterization of thestudy cohort. Offspring of parents with exceptional longevity (OPEL, n=600) and a matched control groupwith parents with usual survival (OPUS, n=600) will be enrolled in this longitudinal study. Newly recruitedsubjects will come from 2 sources: 1) co-enrollment of eligible Ashkenazi Jews from ongoing recruitment inthe Einstein Aging Study and 2) a systematic sample of Ashkenazi Jews from the surrounding community.Baseline clinical evaluation of the study cohortwill include administration of questionnaires (comprehensivepersonal and family medical history, nutrition and activity questionnaires), neuropsychological testing,performance of physical assessment (anthropometries, body fat, ankle and brachial blood pressure,endothelial function and electrocardiogram), and collection of blood samples for biochemical and geneticanalysis. Annual assessments will be conducted for ascertainment of CVD outcomes and follow-upcognitive testing. The Clinical Core will be responsible for the collection and distribution of blood samples tothe appropriate laboratories for testing and will track and retrieve results for transmission to the Statisticsand Data Management Core. The Core will also provide services such as scheduling visits, maintenance ofaccurate contact information for the cohort, as well as other retention activities.
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