The Administrative Core will manage the overall progress of the Program Project with the ultimate goal of defining the neurobiological basis of the therapeutic window of opportunity for estrogen and progesterone. The Administrative Core will: 1) hold overall responsibility for the administration of the program project, 2) manage the fiscal aspects of the Program Project, including the set up of project and core accounts, the appointment of new employees and re-appointment of existing personnel to the program accounts, reconciling accounts, reporting budgets to investigators, ordering of reagents and supplies, tracking orders and reporting expenditures to the UNT Health Science Center as well as NIA personnel, 3) manage the interactions between projects and cores, provide statistical support for all projects, and procure and distribute human tissue to the projects, and 4) foster an environment for the intellectual interactions of program investigators and between investigators at the UNT Health Science Center community, and with the research community at large.

Public Health Relevance

The successful interactions among Projects and Cores have, and will continue to be monitored and managed by the Administrative Core through regular meetings/teleconferences. In addition, the Administrative Core will also help shape the long-term goal of identifying improved or novel therapeutic strategies for treating age-associated disorders associated with the menopause and post-menopausal period, including Alzheimer's disease.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (O2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Texas
Fort Worth
United States
Zip Code
Kaja, Simon; Sumien, Nathalie; Shah, Vidhi V et al. (2015) Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels. Mol Neurobiol 52:545-54
Petrone, Ashley B; Simpkins, James W; Barr, Taura L (2014) 17?-estradiol and inflammation: implications for ischemic stroke. Aging Dis 5:340-5
Li, W; Huang, R; Chen, Z et al. (2014) PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience 274:153-61
Chen, Fangfang; Qi, Wen; Sun, Jiahong et al. (2014) Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in the HT22 cell assay. Fitoterapia 97:156-63
Payne, Andrew J; Kaja, Simon; Naumchuk, Yuliya et al. (2014) Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina. Int J Mol Sci 15:1865-86
Cunningham, Rebecca L; Singh, Meharvan; O'Bryant, Sid E et al. (2014) Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease. J Alzheimers Dis 40:563-73
Kaja, Simon; Naumchuk, Yuliya; Grillo, Stephanie L et al. (2014) Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model. Vision Res 94:16-23
Petrone, Ashley B; Gatson, Joshua W; Simpkins, James W et al. (2014) Non-feminizing estrogens: a novel neuroprotective therapy. Mol Cell Endocrinol 389:40-7
Xie, Luokun; Sun, Fen; Wang, Jixian et al. (2014) mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia. J Immunol 192:6009-19
Faure, Lionel; Nagarajan, Subbiah; Hwang, Hyeondo et al. (2014) Synthesis of phenoxyacyl-ethanolamides and their effects on fatty acid amide hydrolase activity. J Biol Chem 289:9340-51

Showing the most recent 10 out of 58 publications