Core A, the Administrative Core will be the focal point of the three projects and two other cores of the Program. The Administrative Core will provide a variety of key administrative and secretarial functions that are central to each and every project and component of the Program. Since 67% of the Program will be undertaken at Wichita State University, the Administrative Core will be housed on that campus as well under the direction of Dr. George Bousfield, the Principal Investigator of the Program. Extensive administrative experience will be provided by Dr. Jeffrey May, Co-Core Leader. However, the Administrative Core will serve the Projects and Project Leaders on the other campuses, including the Kansas City campus of the University of Kansas Medical Center, Dr. Raj Kumar;and the University of Nebraska Medical Center, Drs. John Davis, S.K. Roy, and E. Bedows. The Administrative Core will organize an annual site visit by the external advisory board. The board has been selected for expertise in gonadotropin structure and function (Dr.James Dias), gonadotropin signal transduction (Dr. Mary Hunzicker-Dunn), gonadotropin molecular biology (Dr. Irving Boime), and FSH isoforms (Dr.Alfredo Ulloa-Aguirre).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG029531-05
Application #
8449609
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$118,338
Indirect Cost
$37,285
Name
Wichita State University
Department
Type
DUNS #
053078127
City
Wichita
State
KS
Country
United States
Zip Code
67260
Hua, G; Lv, X; He, C et al. (2016) YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene 35:2247-65
Wang, Huizhen; Butnev, Vladimir; Bousfield, George R et al. (2016) A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7Δ) Asn(24Δ)) FSHβ subunit fails to rescue Fshb null mice. Mol Cell Endocrinol 426:113-24
Wang, Huizhen; Hastings, Richard; Miller, William L et al. (2016) Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage. Mol Cell Endocrinol 419:124-38
Wang, Huizhen; May, Jacob; Butnev, Viktor et al. (2016) Evaluation of in vivo bioactivities of recombinant hypo- (FSH(21/18)) and fully- (FSH(24)) glycosylated human FSH glycoforms in Fshb null mice. Mol Cell Endocrinol 437:224-236
Wang, Huizhen; Graham, Ian; Hastings, Richard et al. (2015) Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. J Biol Chem 290:2699-714
He, C; Lv, X; Hua, G et al. (2015) YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene 34:6040-54
He, Chunbo; Mao, Dagan; Hua, Guohua et al. (2015) The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med 7:1426-49
Butnev, Viktor Y; Butnev, Vladimir Y; May, Jeffrey V et al. (2015) Production, purification, and characterization of recombinant hFSH glycoforms for functional studies. Mol Cell Endocrinol 405:42-51
Jiang, Chao; Hou, Xiaoying; Wang, Cheng et al. (2015) Hypoglycosylated hFSH Has Greater Bioactivity Than Fully Glycosylated Recombinant hFSH in Human Granulosa Cells. J Clin Endocrinol Metab 100:E852-60
Bousfield, George R; Butnev, Vladimir Y; White, William K et al. (2015) Comparison of Follicle-Stimulating Hormone Glycosylation Microheterogenity by Quantitative Negative Mode Nano-Electrospray Mass Spectrometry of Peptide-N Glycanase-Released Oligosaccharides. J Glycomics Lipidomics 5:

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