Core A, the Administrative Core will be the focal point of the three projects and two other cores of the Program. The Administrative Core will provide a variety of key administrative and secretarial functions that are central to each and every project and component of the Program. Since 67% of the Program will be undertaken at Wichita State University, the Administrative Core will be housed on that campus as well under the direction of Dr. George Bousfield, the Principal Investigator of the Program. Extensive administrative experience will be provided by Dr. Jeffrey May, Co-Core Leader. However, the Administrative Core will serve the Projects and Project Leaders on the other campuses, including the Kansas City campus of the University of Kansas Medical Center, Dr. Raj Kumar;and the University of Nebraska Medical Center, Drs. John Davis, S.K. Roy, and E. Bedows. The Administrative Core will organize an annual site visit by the external advisory board. The board has been selected for expertise in gonadotropin structure and function (Dr.James Dias), gonadotropin signal transduction (Dr. Mary Hunzicker-Dunn), gonadotropin molecular biology (Dr. Irving Boime), and FSH isoforms (Dr.Alfredo Ulloa-Aguirre).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG029531-05
Application #
8449609
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$118,338
Indirect Cost
$37,285
Name
Wichita State University
Department
Type
DUNS #
053078127
City
Wichita
State
KS
Country
United States
Zip Code
67260
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Talbott, Heather; Delaney, Abigail; Zhang, Pan et al. (2014) Effects of IL8 and immune cells on the regulation of luteal progesterone secretion. Reproduction 148:21-31
Fu, David; Lv, Xiangmin; Hua, Guohua et al. (2014) YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors. Endocr Relat Cancer 21:297-310
Ulloa-Aguirre, Alfredo; Reiter, Eric; Bousfield, George et al. (2014) Constitutive activity in gonadotropin receptors. Adv Pharmacol 70:37-80
Kumar, T Rajendra (2014) Extragonadal FSH receptor: is it real? Biol Reprod 91:99
Bousfield, George R; Butnev, Vladimir Y; Butnev, Viktor Y et al. (2014) Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)). Mol Cell Endocrinol 382:989-97
Ulloa-Aguirre, Alfredo; Dias, James A; Bousfield, George et al. (2013) Trafficking of the follitropin receptor. Methods Enzymol 521:17-45
Bousfield, George R; Dias, James A (2011) Synthesis and secretion of gonadotropins including structure-function correlates. Rev Endocr Metab Disord 12:289-302
Kumar, T Rajendra (2011) The "Glow"rious Sertoli and germ cells: mouse testis development visualized in multi-colors. Biol Reprod 84:201-4
Wehbi, Vanessa; Tranchant, Thibaud; Durand, Guillaume et al. (2010) Partially deglycosylated equine LH preferentially activates beta-arrestin-dependent signaling at the follicle-stimulating hormone receptor. Mol Endocrinol 24:561-73

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