these studies are significant and innovative because they have strong relevance to our understanding of the possible mechanistic etiology of AD, potentially facilitating therapy, and to AD genetics, facilitating early diagnosis and treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG030128-04
Application #
8380112
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
4
Fiscal Year
2012
Total Cost
$277,176
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Gold, Brian T; Brown, Christopher A; Hakun, Jonathan G et al. (2017) Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiol Aging 58:102-111
Brown, Christopher A; Johnson, Nathan F; Anderson-Mooney, Amelia J et al. (2017) Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. Neuroimage Clin 13:106-115
DiBattista, Amanda M; Dumanis, Sonya B; Newman, Joshua et al. (2016) Identification and modification of amyloid-independent phenotypes of APOE4 mice. Exp Neurol 280:97-105
Di Battista, Amanda M; Heinsinger, Nicolette M; Rebeck, G William (2016) Alzheimer's Disease Genetic Risk Factor APOE-?4 Also Affects Normal Brain Function. Curr Alzheimer Res 13:1200-1207
Yang, Longyu; Liu, Chia-Chen; Zheng, Honghua et al. (2016) LRP1 modulates the microglial immune response via regulation of JNK and NF-?B signaling pathways. J Neuroinflammation 13:304
Cacciottolo, Mafalda; Christensen, Amy; Moser, Alexandra et al. (2016) The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging 37:47-57
Luo, Jia; Lee, Sue H; VandeVrede, Lawren et al. (2016) A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Mol Neurodegener 11:35
Tai, Leon M; Thomas, Riya; Marottoli, Felecia M et al. (2016) The role of APOE in cerebrovascular dysfunction. Acta Neuropathol 131:709-23
Wren, Melissa C; Zhao, Jing; Liu, Chia-Chen et al. (2015) Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Mol Neurodegener 10:46
Zhou, Ye; Zhao, Wenjuan; Al-Muhtasib, Nour et al. (2015) APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice. J Alzheimers Dis 46:365-74

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