Is it true that males are healthier than females but die younger? If so, why? We plan demographic analyses to address these two overarching questions concerning the health-survival paradox. First, to what extent is the paradox true? How general is it? * According to which definitions and measures and along which dimensions are men healthier than women? * How do male-female morbidity and mortality differences vary with age? * How do they vary over place? * How have they varied over time? * How do they vary across species of mammals, birds, reptiles, amphibians and fish? Second, to the extent that the paradox is true, why is this the case? Various social and biological hypotheses will be tested by analyzing: Human and nonhuman lifetables (Project 1); Survey and register data on humans in Denmark (Project 2); Survey data on humans in the United States (Project 3) and in Japan, the Philippines and Singapore (Project 4); Longitudinal observations on baboons in the wild in Kenya (Project 5); Longitudinal data on lemurs in the wild on Madagascar and in captivity at Duke and in France (Project 6);and Laboratory data on fruit flies (Project 7). The combination of informative animal models and high-quality human data and sophisticated demographic analyses will provide a deeper understanding of the basis for sex differences in health and survival and of opportunities to reduce these differences.

Public Health Relevance

Is it true that males are healthier than females but die younger? If so, why? This program project supports research projects that address these questions concerning the human health-survival paradox. Findings will provide a deeper understanding of the basis for sex differences in health and survival-and of the opportunities that society and particularly health professionals have to improve health and survival for males and females.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG031719-05
Application #
8531094
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J2))
Program Officer
Haaga, John G
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$663,624
Indirect Cost
$90,992
Name
Duke University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Oksuzyan, A; Shkolnikova, M; Vaupel, J W et al. (2014) Sex differences in health and mortality in Moscow and Denmark. Eur J Epidemiol 29:243-52
Gesquiere, Laurence R; Ziegler, Toni E; Chen, Patricia A et al. (2014) Measuring fecal testosterone in females and fecal estrogens in males: comparison of RIA and LC/MS/MS methods for wild baboons (Papio cynocephalus). Gen Comp Endocrinol 204:141-9
Archie, Elizabeth A; Tung, Jenny; Clark, Michael et al. (2014) Social affiliation matters: both same-sex and opposite-sex relationships predict survival in wild female baboons. Proc Biol Sci 281:
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Alberts, Susan C; Altmann, Jeanne; Brockman, Diane K et al. (2013) Reproductive aging patterns in primates reveal that humans are distinct. Proc Natl Acad Sci U S A 110:13440-5
Runcie, Daniel E; Wiedmann, Ralph T; Archie, Elizabeth A et al. (2013) Social environment influences the relationship between genotype and gene expression in wild baboons. Philos Trans R Soc Lond B Biol Sci 368:20120345
Lindahl-Jacobsen, Rune; Hanson, Heidi A; Oksuzyan, Anna et al. (2013) The male-female health-survival paradox and sex differences in cohort life expectancy in Utah, Denmark, and Sweden 1850-1910. Ann Epidemiol 23:161-6
Babbitt, Courtney C; Tung, Jenny; Wray, Gregory A et al. (2012) Changes in gene expression associated with reproductive maturation in wild female baboons. Genome Biol Evol 4:102-9
Gesquiere, Laurence R; Onyango, Patrick O; Alberts, Susan C et al. (2011) Endocrinology of year-round reproduction in a highly seasonal habitat: environmental variability in testosterone and glucocorticoids in baboon males. Am J Phys Anthropol 144:169-76

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