The Scientific Core provides an organizational structure for scientific efforts common to all projects within the program to achieve the overall goals and vision of the Program Project as an integrated investigation in diseases caused by VZV in the elderly. The Core Leader, Dr. Maria Nagel, meets with the Clinical Coordinator daily to prioritize scientific efforts on all human and monkey specimens and to plan strategies and evaluate data. The Scientific Core provides support for the Clinical Coordinator, who will acquire, bank, process and computerize all tissue from humans in Projects 1 and 2 and from monkeys in Project 3, as well as ensure compliance with regulatory bodies including the Colorado Multiple Institutional Review Board. The Scientific Core also provides support in all 3 projects for: a bioinformatics expert to assist with RNA sequencing, data analysis and interpretation, and training of laboratory personnel in these analyses; a statistical consultant; an editorial consultant and publication costs; common-use supplies and equipment for tissue culture, PCR and gene expression profiling/RNA sequencing; and continuing service contracts, maintenance and repair of heavy equipment and computer costs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG032958-11
Application #
9491546
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2009-03-01
Project End
2023-12-31
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
11
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Cohrs, Randall J; Badani, Hussain; Baird, Nicholas L et al. (2017) Induction of varicella zoster virus DNA replication in dissociated human trigeminal ganglia. J Neurovirol 23:152-157
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Nagel, Maria A; Jones, Dallas; Wyborny, Ann (2017) Varicella zoster virus vasculopathy: The expanding clinical spectrum and pathogenesis. J Neuroimmunol 308:112-117
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Gilden, Don; White, Teresa; Boyer, Philip J et al. (2016) Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta. J Infect Dis 213:1866-71
Keller, Amy C; Badani, Hussain; McClatchey, P Mason et al. (2016) Varicella zoster virus infection of human fetal lung cells alters mitochondrial morphology. J Neurovirol 22:674-682
Gilden, Don; White, Teresa; Khmeleva, Nelly et al. (2016) Blinded search for varicella zoster virus in giant cell arteritis (GCA)-positive and GCA-negative temporal arteries. J Neurol Sci 364:141-3

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