? Core A The Administrative Core will be responsible for coordinating the scientific and financial activities of the Program Project, daily administration and collaborative research activities of the overall Program Project. The scientific coordination will be supervised by the Program Project Director, Dr. Karsenty. The duties of this core, which are described in the body of the application, will include: - Scientific leadership to foster the overall progress of research, scientific focus, integrity and ethical conduct and support to the Projects and Core B - Administrative support and budget management - Establishing policies for effective utilization of Core B; and archiving of copies of Core B assembled data - Supervision of procurement and personnel reports - Coordinating institutional authorizations for recombinant DNA, radioisotopes, and vertebrate animals - Organization of project-related records, such as publications and invited seminars by the Program Project Investigators - Preparation of progress reports to the NIH and other necessary correspondence with NIA program staff - Scheduling monthly meetings of the Program Project investigators, and annual visits of the External Advisory Committee - Facilitating and providing data Management and services - Bringing internationally-known scientists to Columbia to consult with the Project Leaders - Scheduling of meetings and talks of visiting scientists - Facilitation of Institutional Review Board submissions - Maintenance of overall progress of research, scientific focus, integrity and ethical conduct

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZAG1)
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Columbia University (N.Y.)
New York
United States
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De Vadder, Filipe; Grasset, Estelle; Mannerås Holm, Louise et al. (2018) Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Proc Natl Acad Sci U S A 115:6458-6463
Obri, Arnaud; Khrimian, Lori; Karsenty, Gerard et al. (2018) Osteocalcin in the brain: from embryonic development to age-related decline in cognition. Nat Rev Endocrinol 14:174-182
Khrimian, Lori; Obri, Arnaud; Karsenty, Gerard (2017) Modulation of cognition and anxiety-like behavior by bone remodeling. Mol Metab 6:1610-1615
Khrimian, Lori; Obri, Arnaud; Ramos-Brossier, Mariana et al. (2017) Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med 214:2859-2873
Mosialou, Ioanna; Shikhel, Steven; Liu, Jian-Min et al. (2017) MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature 543:385-390
Mera, Paula; Laue, Kathrin; Wei, Jianwen et al. (2016) Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab 5:1042-7
Galán-Díez, Marta; Isa, Adiba; Ponzetti, Marco et al. (2016) Normal hematopoiesis and lack of ?-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations. Biochim Biophys Acta 1863:490-498
Ortuño, María José; Robinson, Samuel T; Subramanyam, Prakash et al. (2016) Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect. Nat Med 22:1170-1179
Kode, A; Mosialou, I; Manavalan, S J et al. (2016) FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice. Leukemia 30:1-13
Shimazu, Junko; Wei, Jianwen; Karsenty, Gerard (2016) Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148. Cell Rep 15:27-35

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