Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage'system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.

Public Health Relevance

Aging humans and animals experience decline in multiple essential systems, that is, functional senescence. Aging is also accompanied by a progressive increase in mortality rate. The purpose of this core is to conduct life table experiments required to test whether slowing the progress of functional senescence is sufficient to actually slow the demographic features of aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG033561-02
Application #
8377002
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
2
Fiscal Year
2012
Total Cost
$143,262
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Cannon, Leah; Bodmer, Rolf (2016) Genetic manipulation of cardiac ageing. J Physiol 594:2075-83
Ivy, Jessica R; Drechsler, Maik; Catterson, James H et al. (2015) Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLoS One 10:e0134620
Thimgan, Matthew S; Seugnet, Laurent; Turk, John et al. (2015) Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Sleep 38:801-14
Diop, Soda Balla; Bisharat-Kernizan, Jumana; Birse, Ryan Tyge et al. (2015) PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase. Cell Rep :
Lucey, Brendan P; Leahy, Averi; Rosas, Regine et al. (2015) A new model to study sleep deprivation-induced seizure. Sleep 38:777-85
Diop, Soda Balla; Bodmer, Rolf (2015) Gaining Insights into Diabetic Cardiomyopathy from Drosophila. Trends Endocrinol Metab 26:618-27
Dissel, Stephane; Seugnet, Laurent; Thimgan, Matthew S et al. (2015) Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Brain Behav Immun 47:75-85
Hardy, Christopher M; Birse, Ryan T; Wolf, Matthew J et al. (2015) Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol 309:R658-67
Lim, Hui-Ying; Wang, Weidong; Chen, Jianming et al. (2014) ROS regulate cardiac function via a distinct paracrine mechanism. Cell Rep 7:35-44
Nishimura, Mayuko; Kumsta, Caroline; Kaushik, Gaurav et al. (2014) A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell 13:431-40

Showing the most recent 10 out of 28 publications