The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in support of the overall program hypothesis that the understanding of the mechanisms of dietary restriction and reduced growth hormone/insulin growth factor (GH/IGF) signaling-dependent cellular protection can be applied to the prevention and treatment of age-related diseases. Mouse breeding colonies of unique genetic and molecular phenotypes which target specific tissue or cellular GH/IGF pathways are the source of offspring to be characterized for longevity, stress resistance, spontaneous cancer development and protection from oxidative damage and established chemotherapy drugs. The core provides an integrative framework for assessment of common outcomes across the individual projects needs.
The Animal and Biostatistics Core will apply the expertise of its leaders to improve the design, execution, interpretation, and publication of all animal studies proposed in this program project. The Animal and Biostatistics Core will monitor all animal experiments using specific mouse models and standardized experimental protocols to provide an integrative framework for assessment of common outcomes across the individual projects.
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|Okada, Alan K; Teranishi, Kazuki; Lobo, Fleur et al. (2017) The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep 7:7802|
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|Hine, Christopher; Kim, Hyo-Jeong; Zhu, Yan et al. (2017) Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab 25:1320-1333.e5|
|Ayers, Emmeline; Shapiro, Miriam; Holtzer, Roee et al. (2017) Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults. J Clin Psychiatry 78:e529-e536|
|Balasubramanian, Priya; Longo, Valter D (2016) Growth factors, aging and age-related diseases. Growth Horm IGF Res 28:66-8|
|Mirzaei, Hamed; Raynes, Rachel; Longo, Valter D (2016) The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care 19:74-9|
|Marini, Cecilia; Ravera, Silvia; Buschiazzo, Ambra et al. (2016) Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt. Sci Rep 6:25092|
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