The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in support of the overall program hypothesis that the understanding of the mechanisms of dietary restriction and reduced growth hormone/insulin growth factor (GH/IGF) signaling-dependent cellular protection can be applied to the prevention and treatment of age-related diseases. Mouse breeding colonies of unique genetic and molecular phenotypes which target specific tissue or cellular GH/IGF pathways are the source of offspring to be characterized for longevity, stress resistance, spontaneous cancer development and protection from oxidative damage and established chemotherapy drugs. The core provides an integrative framework for assessment of common outcomes across the individual projects needs.
The Animal and Biostatistics Core will apply the expertise of its leaders to improve the design, execution, interpretation, and publication of all animal studies proposed in this program project. The Animal and Biostatistics Core will monitor all animal experiments using specific mouse models and standardized experimental protocols to provide an integrative framework for assessment of common outcomes across the individual projects.
|Huffman, Derek M; Farias Quipildor, Gabriela; Mao, Kai et al. (2016) Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell 15:181-6|
|Sreekumar, Parameswaran G; Ishikawa, Keijiro; Spee, Chris et al. (2016) The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci 57:1238-53|
|Longo, Valter D; Panda, Satchidananda (2016) Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab 23:1048-59|
|Lee, Changhan; Kim, Kyung Hwa; Cohen, Pinchas (2016) MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med 100:182-187|
|Mitchell, Sarah J; Madrigal-Matute, Julio; Scheibye-Knudsen, Morten et al. (2016) Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab 23:1093-112|
|Marini, Cecilia; Ravera, Silvia; Buschiazzo, Ambra et al. (2016) Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt. Sci Rep 6:25092|
|Callisaya, Michele L; Ayers, Emmeline; Barzilai, Nir et al. (2016) Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study. J Alzheimers Dis 53:1043-52|
|Mirzaei, Hamed; Raynes, Rachel; Longo, Valter D (2016) The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care 19:74-9|
|Choi, In Young; Piccio, Laura; Childress, Patra et al. (2016) A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep 15:2136-46|
|Vernieri, Claudio; Casola, Stefano; Foiani, Marco et al. (2016) Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov 6:1315-1333|
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