The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion ofthe broader goals and objections ofthe Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in nutrient-related factors alters the environmental milieu of stem cells in bone. Each ofthe three projects investigates different aspects ofthese nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B fadlities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.

Public Health Relevance

Core B will provide assay services related to bone histology, biomechanics, bone imaging, and serum biochemistry, and is therefore essential to successful completion of the Program Project goals and objectives.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J3))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgia Regents University
United States
Zip Code
Refaey, Mona El; McGee-Lawrence, Meghan E; Fulzele, Sadanand et al. (2017) Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss. J Bone Miner Res 32:2182-2193
Carbone, L D; B?žková, P; Fink, H A et al. (2017) Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study. Osteoporos Int 28:1631-1640
Yang, Nianlan; Baban, Babak; Isales, Carlos M et al. (2017) Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss. PLoS One 12:e0181133
Carbone, Laura D; B?žková, Petra; Fink, Howard A et al. (2017) Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study. Calcif Tissue Int 100:599-608
McGee-Lawrence, Meghan E; Wenger, Karl H; Misra, Sudipta et al. (2017) Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice. Endocrinology 158:1160-1171
Hodges, Walter M; O'Brien, Frederick; Fulzele, Sadanand et al. (2017) Function of microRNAs in the Osteogenic Differentiation and Therapeutic Application of Adipose-Derived Stem Cells (ASCs). Int J Mol Sci 18:
Durham, Emily; Howie, R Nicole; Parsons, Trish et al. (2017) Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int 101:300-311
Murphy, Cameron; Withrow, Joseph; Hunter, Monte et al. (2017) Emerging role of extracellular vesicles in musculoskeletal diseases. Mol Aspects Med :
Yu, Kanglun; Sellman, David P; Bahraini, Anoosh et al. (2017) Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone. J Orthop Res :
Withrow, Joseph; Murphy, Cameron; Liu, Yutao et al. (2016) Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 18:286

Showing the most recent 10 out of 41 publications