Administrative and biostatistical activities ofthe Program Project will take place in the Administrative Core. Drs. Isales and Hamrick will be responsible for the scientific oversight of the PPG, the direction of research emphasis and the fiscal administration. Dr. Isales will chair the Executive and Scientific Committee meetings and be responsible for preparing all progress reports for these two committees and for the NIA. Dr. Isales will consult with appropriate committee members and Project and Core Leaders in order to effectively resolve all personnel and fiscal issues that may arise. Dr. Isales will be the liaison to the NIA and will ensure that annual non-competing renewal reports and quarterly reports on participant accrual are reported promptly and accurately to the NIA. He will also oversee compliance with regard to MCG's Institutional Review Board's policies, including the requirement that all Project and Core investigators and staff maintain certification in MCG's Research Ethics Training Program. The main purpose of the Biostatistics component is to bring together the information from different sources into an integrated database, and to coordinate the statistical analyses with the focus being on the main goals of the PPG.The Biostatistics faculty will help the investigators ofthe projects to choose appropriate experimental designs and analytical techniques tailored to address specific hypotheses, especially, focusing on justification of the data analysis method to be used for each type of data generated. The Biostatistics component will serve as the focus for data compilation, quality control, data analysis and interpretation support for the PPG, incuding: 1. Design and apply analytical methods to be used in the quantitative studies associated with various projects in the PPG;2. Provide ongoing statistical consultation to research projects, focusing on issues such as experimental design, sample size, aptness and validity of models to be used, power considerations, interpretation of results and preparation of manuscripts for presentations and publications;and 3. Maintain a dataflow system that insures accuracy, security, validation and archiving of all data collected for different projects ofthe PPG.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG036675-02S1
Application #
8508333
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-04-30
Support Year
2
Fiscal Year
2012
Total Cost
$83,490
Indirect Cost
$27,830
Name
Georgia Regents University
Department
Type
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Refaey, Mona El; McGee-Lawrence, Meghan E; Fulzele, Sadanand et al. (2017) Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss. J Bone Miner Res 32:2182-2193
Carbone, L D; B?žková, P; Fink, H A et al. (2017) Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study. Osteoporos Int 28:1631-1640
Yang, Nianlan; Baban, Babak; Isales, Carlos M et al. (2017) Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss. PLoS One 12:e0181133
Carbone, Laura D; B?žková, Petra; Fink, Howard A et al. (2017) Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study. Calcif Tissue Int 100:599-608
McGee-Lawrence, Meghan E; Wenger, Karl H; Misra, Sudipta et al. (2017) Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice. Endocrinology 158:1160-1171
Hodges, Walter M; O'Brien, Frederick; Fulzele, Sadanand et al. (2017) Function of microRNAs in the Osteogenic Differentiation and Therapeutic Application of Adipose-Derived Stem Cells (ASCs). Int J Mol Sci 18:
Durham, Emily; Howie, R Nicole; Parsons, Trish et al. (2017) Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int 101:300-311
Murphy, Cameron; Withrow, Joseph; Hunter, Monte et al. (2017) Emerging role of extracellular vesicles in musculoskeletal diseases. Mol Aspects Med :
Yu, Kanglun; Sellman, David P; Bahraini, Anoosh et al. (2017) Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone. J Orthop Res :
Withrow, Joseph; Murphy, Cameron; Liu, Yutao et al. (2016) Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 18:286

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