Administrative and biostatistical activities ofthe Program Project will take place in the Administrative Core. Drs. Isales and Hamrick will be responsible for the scientific oversight of the PPG, the direction of research emphasis and the fiscal administration. Dr. Isales will chair the Executive and Scientific Committee meetings and be responsible for preparing all progress reports for these two committees and for the NIA. Dr. Isales will consult with appropriate committee members and Project and Core Leaders in order to effectively resolve all personnel and fiscal issues that may arise. Dr. Isales will be the liaison to the NIA and will ensure that annual non-competing renewal reports and quarterly reports on participant accrual are reported promptly and accurately to the NIA. He will also oversee compliance with regard to MCG's Institutional Review Board's policies, including the requirement that all Project and Core investigators and staff maintain certification in MCG's Research Ethics Training Program. The main purpose of the Biostatistics component is to bring together the information from different sources into an integrated database, and to coordinate the statistical analyses with the focus being on the main goals of the PPG.The Biostatistics faculty will help the investigators ofthe projects to choose appropriate experimental designs and analytical techniques tailored to address specific hypotheses, especially, focusing on justification of the data analysis method to be used for each type of data generated. The Biostatistics component will serve as the focus for data compilation, quality control, data analysis and interpretation support for the PPG, including: 1. Design and apply analytical methods to be used in the quantitative studies associated with various projects in the PPG;2. Provide ongoing statistical consultation to research projects, focusing on issues such as experimental design, sample size, aptness and validity of models to be used, power considerations, interpretation of results and preparation of manuscripts for presentations and publications;and 3. Maintain a dataflow system that insures accuracy, security, validation and archiving of all data collected for different projects ofthe PPG.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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Georgia Regents University
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El Refaey, Mona; Zhong, Qing; Hill, William D et al. (2014) Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension. PLoS One 9:e91108
Herberg, Samuel; Kondrikova, Galina; Periyasamy-Thandavan, Sudharsan et al. (2014) Inkjet-based biopatterning of SDF-1? augments BMP-2-induced repair of critical size calvarial bone defects in mice. Bone 67:95-103
Pan, Guodong; Cao, Jay; Yang, Nianlan et al. (2014) Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition. J Biol Chem 289:19373-82
Refaey, Mona El; Zhong, Qing; Ding, Ke-Hong et al. (2014) Impact of dietary aromatic amino acids on osteoclastic activity. Calcif Tissue Int 95:174-82
Herberg, Samuel; Shi, Xingming; Johnson, Maribeth H et al. (2013) Stromal cell-derived factor-1? mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLoS One 8:e58207
Arounleut, Phonepasong; Bialek, Peter; Liang, Li-Fang et al. (2013) A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength. Exp Gerontol 48:898-904
Bollag, Wendy B; Isales, Carlos M (2013) GRowing an epidermal tumor. J Invest Dermatol 133:2659-62
Fulzele, Sadanand; Chothe, Paresh; Sangani, Rajnikumar et al. (2013) Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis. Stem Cell Res 10:36-47
Herberg, Samuel; Fulzele, Sadanand; Yang, Nianlan et al. (2013) Stromal cell-derived factor-1* potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. Tissue Eng Part A 19:1-13
Bowser, Matthew; Herberg, Samuel; Arounleut, Phonepasong et al. (2013) Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol 48:290-7

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