The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion ofthe broader goals and objections ofthe Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in nutrient-related factors alters the environmental milieu of stem cells in bone. Each ofthe three projects investigates different aspects ofthese nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B fadlities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.
Core B will provide assay services related to bone histology, biomechanics, bone imaging, and serum biochemistry, and is therefore essential to successful completion of the Program Project goals and objectives.
|Kolhe, Ravindra; Mondal, Ashis K; Pundkar, Chetan et al. (2018) Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells. Nutrients 10:|
|Yu, Kanglun; Sellman, David P; Bahraini, Anoosh et al. (2018) Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone. J Orthop Res 36:653-662|
|Kesterke, Matthew J; Judd, Margaret A; Mooney, Mark P et al. (2018) Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice. J Anat 233:46-54|
|Howie, R Nicole; Herberg, Samuel; Durham, Emily et al. (2018) Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. Int J Oral Sci 10:25|
|Elsayed, Ranya; Abraham, Pheba; Awad, Mohamed E et al. (2018) Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone 110:141-149|
|Murphy, Cameron; Withrow, Joseph; Hunter, Monte et al. (2018) Emerging role of extracellular vesicles in musculoskeletal diseases. Mol Aspects Med 60:123-128|
|Roser-Page, Susanne; Vikulina, Tatyana; Yu, Kanglun et al. (2018) Neutralization of CD40 ligand costimulation promotes bone formation and accretion of vertebral bone mass in mice. Rheumatology (Oxford) 57:1105-1114|
|Bollag, Wendy B; Choudhary, Vivek; Zhong, Qing et al. (2018) Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo. Mol Cell Endocrinol 461:22-31|
|Kim, Beom-Jun; Lee, Seung Hun; Kwak, Mi Kyung et al. (2018) Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: a nationwide population-based study. Aging (Albany NY) 10:2051-2061|
|Kim, B-J; Lee, S H; Isales, C M et al. (2018) The positive association of total protein intake with femoral neck strength (KNHANES IV). Osteoporos Int 29:1397-1405|
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