?PROJECT 1: PET MEASURES OF TAU AND AMYLOID PATHOLOGY. We propose in Project 1 to evaluate Tau PET measures in the entire Harvard Aging Brain Study (HABS) cohort, focusing on testing whether the PET measures of Tau and A? are related to each other and to measures of brain structure and function. This research will facilitate the intense efforts currently underway to develop disease-modifying treatments of Alzheimer's disease (AD), aided by biomarkers of these hallmark lesions that could potentially aid in diagnosis, disease staging, drug development, and treatment monitoring. In the proposed competing continuation, HABS participants will undergo PiB and T807 PET (estimated N=250; acquired in Core C: Imaging Core), with a representative subset (N=100) undergoing longitudinal T807 and FDG PET, in order to achieve the following aims:
Aim 1 : To characterize T807 PET in the HABS cohort in order to determine the anatomy of specific binding, relate binding to age, gender and APOE genotype, and identify suitable standard proxy measures of global burden and/or its stages of longitudinal change.
Aim 2 : To assess the interrelationships of Tau and A? deposition and their differential impact on regional connectivity, synaptic integrity, brain volume, and CSF markers.
Aim 3 : To evaluate the longitudinal change in Tau accumulation in relation to A?, connectivity, synaptic integrity, atrophy, and CSF markers, as well as to longitudinal cognition, coordinating with Project 4. !
| Rieckmann, Anna; Johnson, Keith A; Sperling, Reisa A et al. (2018) Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging. Proc Natl Acad Sci U S A 115:10160-10165 |
| Makaretz, Sara J; Quimby, Megan; Collins, Jessica et al. (2018) Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. J Neurol Neurosurg Psychiatry 89:1024-1031 |
| Lois, Cristina; Gonzalez, Ivan; Johnson, Keith A et al. (2018) PET imaging of tau protein targets: a methodology perspective. Brain Imaging Behav : |
| d'Oleire Uquillas, Federico; Jacobs, Heidi I L; Biddle, Kelsey D et al. (2018) Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry 8:282 |
| Donovan, Nancy J; Locascio, Joseph J; Marshall, Gad A et al. (2018) Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. Am J Psychiatry 175:530-537 |
| Properzi, Michael J; Buckley, Rachel F; Chhatwal, Jasmeer P et al. (2018) Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage 186:446-454 |
| Hanseeuw, Bernard J; Jonas, Victoria; Jackson, Jonathan et al. (2018) Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry : |
| Lee, Catherine; Betensky, Rebecca A; Alzheimer's Disease Neuroimaging Initiative (2018) Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease. Stat Med 37:914-932 |
| Jacobs, Heidi I L; Hedden, Trey; Schultz, Aaron P et al. (2018) Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci 21:424-431 |
| Chiou, Sy Han; Austin, Matthew D; Qian, Jing et al. (2018) Transformation model estimation of survival under dependent truncation and independent censoring. Stat Methods Med Res :962280218817573 |
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