The main objective of the Administrative Core is to provide leadership, coordination of effort, statistical advice, managerial support, and facilitation for the overall operation ofthe program project grant. The program project grant will be under the directorship of Dr. Lynda F. Bonewald and Co-Director, Dr. Mark Johnson. Dr. Bonewald has been the director of a very successful program project entitled "Osteocyte Function and Response to Mechanical Loading" for 11 years and therefore has the skills and experience to insure the success of this application.
The specific aims of this core are: 1).To provide leadership, management, and statistical skills necessary to coordinate and to experimentally design the activities of the program. 2). To coordinate and schedule the activities of the Internal and Extemal Advisory Boards, the Pis meetings, and any support consultants. 3). To coordinate scientific presentations locally and at national and intemational meetings. 4). To provide for the development and education of students and postdoctoral fellows involved in the program including seminars and data meetings. 5). To provide staff support in the fomn of budgetary support and review, preparation of grant reports, written communications, manuscripts, and other supportive activities. The program project will contain four subprojects, an administrative core and two support cores, the Muscle/Bone Phenotyping Core and the Transgenic and Mechanical Loading Core. The Director, Co-Director, Principal Investigators and Core Directors will meet with the Internal Advisory Council at least twice a year and with the Extemal Advisory Board once a year. This core will insure the success of each subproject and core.

Public Health Relevance

The inclusion of this Administrative Core is necessary to insure the success of the program project. This program project focuses on a devastating medical problem that increases with age, that of osteoporosis and aging sarcopenia, which usually occur concun'ently. The proposed subprojects are novel, innovative and relevant to this issue and should provide insight and means to either prevent or treat these conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG039355-03
Application #
8663802
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$107,809
Indirect Cost
$35,936
Name
University of Missouri Kansas City
Department
Type
DUNS #
010989619
City
Kansas City
State
MO
Country
United States
Zip Code
64110
Thiagarajan, Ganesh; Lu, Yunkai; Dallas, Mark et al. (2014) Experimental and finite element analysis of dynamic loading of the mouse forearm. J Orthop Res 32:1580-8
Huang, Jian; Hsu, Yi-Hsiang; Mo, Chenglin et al. (2014) METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-?B signaling pathway. J Bone Miner Res 29:1531-40
Javaheri, Behzad; Stern, Amber Rath; Lara, Nuria et al. (2014) Deletion of a single *-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res 29:705-15
Pan, Zui; Brotto, Marco; Ma, Jianjie (2014) Store-operated Ca2+ entry in muscle physiology and diseases. BMB Rep 47:69-79
Dallas, Sarah L; Prideaux, Matthew; Bonewald, Lynda F (2013) The Osteocyte: An Endocrine Cell and More. Endocr Rev :