The mission of the Mouse Phenotyping and Pathological Assessment (MPPA) Core is to provide the necessary expertise and infrastructure to assess the impact of removing senescent cells (Subproject 1) or their effects (Subprojects 2-4) on measures of physical function, body composition, immune status, and age related pathology. These outcomes of healthspan have been selected for their stand-alone importance and established relationships with frailty, disability, institutionalization, and longevity in older individuals. The ability to conduct these outcomes in mice will greatly enhance our ability to translate the basic biology of aging into clinical application;the overarching goal of the Program Project. The MPPA Core will also be responsible for the banking and distribution of tissues to organ system-based Theme Leaders, and advancing the Aging Animal Medical Record in partnership with the Administrative Core (Core A) and Systems Biology and Bioinformatics Core (Core C).
As an integral component of the Program Project, the MPPA Core will examine whether interventions targeting senescent cells or their senescence associated secretory phenotype improve key determinants of healthspan in laboratory mice. Understanding how interventions that impact biological mechanisms of aging affect not only lifespan but disability, frailty, and onset of disease is a critical step for translational research on aging.
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|Xu, Ming; Tchkonia, Tamar; Kirkland, James L (2016) Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction. Pharmacol Res 111:152-4|
|Baker, Darren J; Childs, Bennett G; Durik, Matej et al. (2016) Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530:184-9|
|Palmer, Allyson K; Kirkland, James L (2016) Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol 86:97-105|
|Schafer, Marissa J; White, Thomas A; Evans, Glenda et al. (2016) Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. Diabetes 65:1606-15|
|Kirkland, James L (2016) Translating the Science of Aging into Therapeutic Interventions. Cold Spring Harb Perspect Med 6:a025908|
|Ye, Hong; Wang, Xiaofang; Sussman, Caroline R et al. (2016) Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies. J Am Soc Nephrol 27:1312-20|
|Huffman, Derek M; Schafer, Marissa J; LeBrasseur, Nathan K (2016) Energetic interventions for healthspan and resiliency with aging. Exp Gerontol 86:73-83|
|Zhu, Yi; Tchkonia, Tamara; Fuhrmann-Stroissnigg, Heike et al. (2016) Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell 15:428-35|
|Xu, Ming; Palmer, Allyson K; Ding, Husheng et al. (2015) Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife 4:e12997|
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