The mission of the Mouse Phenotyping and Pathological Assessment (MPPA) Core is to provide the necessary expertise and infrastructure to assess the impact of removing senescent cells (Subproject 1) or their effects (Subprojects 2-4) on measures of physical function, body composition, immune status, and age related pathology. These outcomes of healthspan have been selected for their stand-alone importance and established relationships with frailty, disability, institutionalization, and longevity in older individuals. The ability to conduct these outcomes in mice will greatly enhance our ability to translate the basic biology of aging into clinical application;the overarching goal of the Program Project. The MPPA Core will also be responsible for the banking and distribution of tissues to organ system-based Theme Leaders, and advancing the Aging Animal Medical Record in partnership with the Administrative Core (Core A) and Systems Biology and Bioinformatics Core (Core C).

Public Health Relevance

As an integral component of the Program Project, the MPPA Core will examine whether interventions targeting senescent cells or their senescence associated secretory phenotype improve key determinants of healthspan in laboratory mice. Understanding how interventions that impact biological mechanisms of aging affect not only lifespan but disability, frailty, and onset of disease is a critical step for translational research on aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG041122-02
Application #
8463947
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$280,406
Indirect Cost
$81,962
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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Xu, Ming; Tchkonia, Tamar; Kirkland, James L (2016) Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction. Pharmacol Res 111:152-4
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Xu, Ming; Palmer, Allyson K; Ding, Husheng et al. (2015) Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife 4:e12997

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