The mission of the Mouse Phenotyping and Pathological Assessment (MPPA) Core is to provide the necessary expertise and infrastructure to assess the impact of removing senescent cells (Subproject 1) or their effects (Subprojects 2-4) on measures of physical function, body composition, immune status, and age related pathology. These outcomes of healthspan have been selected for their stand-alone importance and established relationships with frailty, disability, institutionalization, and longevity in older individuals. The ability to conduct these outcomes in mice will greatly enhance our ability to translate the basic biology of aging into clinical application;the overarching goal of the Program Project. The MPPA Core will also be responsible for the banking and distribution of tissues to organ system-based Theme Leaders, and advancing the Aging Animal Medical Record in partnership with the Administrative Core (Core A) and Systems Biology and Bioinformatics Core (Core C).

Public Health Relevance

As an integral component of the Program Project, the MPPA Core will examine whether interventions targeting senescent cells or their senescence associated secretory phenotype improve key determinants of healthspan in laboratory mice. Understanding how interventions that impact biological mechanisms of aging affect not only lifespan but disability, frailty, and onset of disease is a critical step for translational research on aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-2)
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Mayo Clinic, Rochester
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van Deursen, Jan M (2014) The role of senescent cells in ageing. Nature 509:439-46
Campisi, Judith; Robert, Ladislas (2014) Cell senescence: role in aging and age-related diseases. Interdiscip Top Gerontol 39:45-61
Escande, Carlos; Nin, Veronica; Pirtskhalava, Tamar et al. (2014) Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell 13:951-3
Campisi, Judith (2014) Cell biology: The beginning of the end. Nature 505:35-6
Zhu, Yi; Armstrong, Jacqueline L; Tchkonia, Tamara et al. (2014) Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care 17:324-8
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Childs, Bennett G; Baker, Darren J; Kirkland, James L et al. (2014) Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep 15:1139-53
Tchkonia, Tamara; Thomou, Thomas; Zhu, Yi et al. (2013) Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab 17:644-56
Kirkland, James L (2013) Translating advances from the basic biology of aging into clinical application. Exp Gerontol 48:1-5
Baker, Darren J; Weaver, Robbyn L; van Deursen, Jan M (2013) p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep 3:1164-74

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