The scientific discovery of life course determinants and understanding of within-person processes leading to health-related changes and accelerated aging is a major research priority internationally. The study of aging demands an integrative life course developmental framework, involving interdisciplinary collaborations and advanced methodological approaches for understanding how and why individuals change with age, in both normative and idiosyncratic ways. However, longitudinal research can present remarkable challenges. Replication and comparison of results must include consideration of the age range, birth cohort, culture, health and education of individuals in the sample, differences in measurements, design and statistical analysis, and issues such as rates of response, attrition, and mortality selection. In addition, an understanding of life course processes is embedded within an international and historical context, with consideration of country, culture, and historical differences necessary for evaluating reproducibility and generalizability of particular study findings. A vital function of this application is to further develop, maintain, and make use f an infrastructure for coordinated analysis of international longitudinal studies for advancing knowledge about aging-related change and life course determinants of such changes.
The aims of the overall program project are: 1) To facilitate collaborative, coordinated, and pooled-data analysis of longitudinal studies of aging through the creation of a purpose-built research platform for aggregating and organizing metadata related to study and measurements;2) To evaluate the impact of chronic health conditions and health-related biomarkers on aging-related change in cognitive and physical functioning;3) To evaluate general patterns of population average and individual variation in aging, health, and mortality related change across distinct personality and well-being constructs in major longitudinal studies on aging;and 4) To evaluate the role of early life characteristics and social determinants ion aging-related change in cognition and health, with emphasis on differential risk and exposure processes.

Public Health Relevance

This research program will advance current scientific priorities for integrative, interdisciplinary, and cross-national approaches to research on aging, cognition, personality, and health by making optimal use of major longitudinal studies on aging in direct collaboration with the principal research teams. A core feature of this application is th creation of a common international harmonization platform for longitudinal studies of aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-9 (03))
Program Officer
King, Jonathan W
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Oregon Health and Science University
Schools of Medicine
United States
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Bendayan, Rebecca; Cooper, Rachel; Wloch, Elizabeth G et al. (2016) Hierarchy and Speed of Loss in Physical Functioning: A Comparison Across Older U.S. and English Men and Women. J Gerontol A Biol Sci Med Sci :
Stephan, Blossom C M; Tang, Eugene; Muniz-Terrera, Graciela (2016) Composite risk scores for predicting dementia. Curr Opin Psychiatry 29:174-80
Cadar, Dorina; Stephan, Blossom C M; Jagger, Carol et al. (2016) The role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UK. Int J Geriatr Psychiatry 31:601-10
Kelly, Amanda; Calamia, Matthew; Koval, Andrey et al. (2016) Independent and interactive impacts of hypertension and diabetes mellitus on verbal memory: A coordinated analysis of longitudinal data from England, Sweden, and the United States. Psychol Aging 31:262-73
Cooper, Rachel; Muniz-Terrera, Graciela; Kuh, Diana (2016) Associations of behavioural risk factors and health status with changes in physical capability over 10 years of follow-up: the MRC National Survey of Health and Development. BMJ Open 6:e009962
Praetorius Björk, Marcus; Johansson, Boo; Hassing, Linda B (2016) I forgot when I lost my grip-strong associations between cognition and grip strength in level of performance and change across time in relation to impending death. Neurobiol Aging 38:68-72
Ramsey, Jennifer L; Neupert, Shevaun D; Mroczek, Daniel K et al. (2016) The effects of daily co-occurrence of affect on older adults' reactivity to health stressors. Psychol Health 31:364-78
Brown, Cassandra L; Robitaille, Annie; Zelinski, Elizabeth M et al. (2016) Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study. Psychol Aging 31:831-846
Leszko, Magdalena; Elleman, Lorien G; Bastarache, Emily D et al. (2016) Future Directions in the Study of Personality in Adulthood and Older Age. Gerontology 62:210-5
Muniz-Terrera, Graciela; Robitaille, Annie; Kelly, Amanda et al. (2016) Latent growth models matched to research questions to answer questions about dynamics of change in multiple processes. J Clin Epidemiol :

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