Specific aims of the Measurement and Study Coordination Core (Core B) involve facilitating comparative and replicable research based on coordinated or pooled-data analysis of longitudinal studies of aging. The focus is on developing tools and documentation to support the identification of relevant studies for answering particular questions and to enable rigorous cross-study comparison and data harmonization activities. A purpose-built website enabling organization and aggregation of study and measurement related information will be created (SA1, infrastructure/tools) by the International Harmonization Platform (IHP) team, adapting as necessary the methods, web-based tools and software developed by this group of experts. The website will include and provide access to an extensive searchable cross-study catalogue (SA2, content) for organizing and comparing information about the variables collected by each study, and a contextual database (SA3, content) that will include historical country (or in limited cases region) level information that can be used in addressing cross-national heterogeneity in parallel and pooled analyses. The contextual database will initially be focused on major health and mortality characteristics, average physical height, and standard educational attainment over the range of birth cohorts represented in the lALSA and HALCyon networks. The website will also include a framework to assist in management of all steps of the data harmonization process (SA4, harmonization activities). The website developed by this core will provide a central communication portal for investigators involved in the proposed analyses of affiliated datasets and will include tracking of permissions for data usage from collaborating studies, project management, and a record of published and in progress manuscripts (managed by Core A).

Public Health Relevance

This Core represents the central resources and activities related to creating an international harmonization platform for longitudinal studies of aging. It will provide key support to the subprojects that make up this program project and will furnish essential resources to all researchers eingaged in collaborative interdisciplinary research using data collected in major longitudinal studies on aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG043362-02
Application #
8667970
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$489,114
Indirect Cost
$4,192
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Cadar, Dorina; Robitaille, Annie; Clouston, Sean et al. (2017) An International Evaluation of Cognitive Reserve and Memory Changes in Early Old Age in 10 European Countries. Neuroepidemiology 48:9-20
Bendayan, Rebecca; Kuh, Diana; Cooper, Rachel et al. (2017) Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study. Front Aging Neurosci 9:241
Denier, Nicole; Clouston, Sean A P; Richards, Marcus et al. (2017) Retirement and Cognition: A Life Course View. Adv Life Course Res 31:11-21
Dodge, Hiroko H; Zhu, Jian; Woltjer, Randy et al. (2017) Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. Alzheimers Dement 13:613-623
Bendayan, Rebecca; Cooper, Rachel; Wloch, Elizabeth G et al. (2017) Hierarchy and Speed of Loss in Physical Functioning: A Comparison Across Older U.S. and English Men and Women. J Gerontol A Biol Sci Med Sci 72:1117-1122
Muniz-Terrera, Graciela; Robitaille, Annie; Kelly, Amanda et al. (2017) Latent growth models matched to research questions to answer questions about dynamics of change in multiple processes. J Clin Epidemiol 82:158-166
Clouston, Sean A P; Denier, Nicole (2017) Mental retirement and health selection: Analyses from the U.S. Health and Retirement Study. Soc Sci Med 178:78-86
Graham, Eileen K; Rutsohn, Joshua P; Turiano, Nicholas A et al. (2017) Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers 70:174-186
Dodge, Hiroko H; Zhu, Jian; Hughes, Tiffany F et al. (2017) Cohort effects in verbal memory function and practice effects: a population-based study. Int Psychogeriatr 29:137-148
Stephan, Blossom C M; Tang, Eugene; Muniz-Terrera, Graciela (2016) Composite risk scores for predicting dementia. Curr Opin Psychiatry 29:174-80

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