The scientific discovery of life course determinants and understanding of within-person processes leading to health-related changes and accelerated aging is a major research priority internationally. The study of aging demands an integrative life course developmental framework, involving interdisciplinary collaborations and advanced methodological approaches for understanding how and why individuals change with age, in both normative and idiosyncratic ways. However, longitudinal research can present remarkable challenges. Replication and comparison of results must include consideration of the age range, birth cohort, culture, health and education of individuals in the sample, differences in measurements, design and statistical analysis, and issues such as rates of response, attrition, and mortality selection. In addition, an understanding of life course processes is embedded within an international and historical context, with consideration of country, culture, and historical differences necessary for evaluating reproducibility and generalizability of particular study findings. A vital function of this application is to further develop, maintain, and make use f an infrastructure for coordinated analysis of international longitudinal studies for advancing knowledge about aging-related change and life course determinants of such changes.
The aims of the overall program project are: 1) To facilitate collaborative, coordinated, and pooled-data analysis of longitudinal studies of aging through the creation of a purpose-built research platform for aggregating and organizing metadata related to study and measurements; 2) To evaluate the impact of chronic health conditions and health-related biomarkers on aging-related change in cognitive and physical functioning; 3) To evaluate general patterns of population average and individual variation in aging, health, and mortality related change across distinct personality and well-being constructs in major longitudinal studies on aging; and 4) To evaluate the role of early life characteristics and social determinants ion aging-related change in cognition and health, with emphasis on differential risk and exposure processes.

Public Health Relevance

This research program will advance current scientific priorities for integrative, interdisciplinary, and cross-national approaches to research on aging, cognition, personality, and health by making optimal use of major longitudinal studies on aging in direct collaboration with the principal research teams. A core feature of this application is th creation of a common international harmonization platform for longitudinal studies of aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG043362-05
Application #
9242533
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (03))
Program Officer
King, Jonathan W
Project Start
2013-06-01
Project End
2018-02-28
Budget Start
2017-03-01
Budget End
2018-02-28
Support Year
5
Fiscal Year
2017
Total Cost
$1,417,336
Indirect Cost
$204,204
Name
Oregon Health and Science University
Department
Neurology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Cadar, Dorina; Robitaille, Annie; Clouston, Sean et al. (2017) An International Evaluation of Cognitive Reserve and Memory Changes in Early Old Age in 10 European Countries. Neuroepidemiology 48:9-20
Bendayan, Rebecca; Kuh, Diana; Cooper, Rachel et al. (2017) Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study. Front Aging Neurosci 9:241
Denier, Nicole; Clouston, Sean A P; Richards, Marcus et al. (2017) Retirement and Cognition: A Life Course View. Adv Life Course Res 31:11-21
Dodge, Hiroko H; Zhu, Jian; Woltjer, Randy et al. (2017) Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. Alzheimers Dement 13:613-623
Bendayan, Rebecca; Cooper, Rachel; Wloch, Elizabeth G et al. (2017) Hierarchy and Speed of Loss in Physical Functioning: A Comparison Across Older U.S. and English Men and Women. J Gerontol A Biol Sci Med Sci 72:1117-1122
Muniz-Terrera, Graciela; Robitaille, Annie; Kelly, Amanda et al. (2017) Latent growth models matched to research questions to answer questions about dynamics of change in multiple processes. J Clin Epidemiol 82:158-166
Clouston, Sean A P; Denier, Nicole (2017) Mental retirement and health selection: Analyses from the U.S. Health and Retirement Study. Soc Sci Med 178:78-86
Graham, Eileen K; Rutsohn, Joshua P; Turiano, Nicholas A et al. (2017) Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers 70:174-186
Dodge, Hiroko H; Zhu, Jian; Hughes, Tiffany F et al. (2017) Cohort effects in verbal memory function and practice effects: a population-based study. Int Psychogeriatr 29:137-148
Stephan, Blossom C M; Tang, Eugene; Muniz-Terrera, Graciela (2016) Composite risk scores for predicting dementia. Curr Opin Psychiatry 29:174-80

Showing the most recent 10 out of 45 publications