The Imaging Core C is comprised of a centralized cutting-edge microscopy facility, absolutely essential to the research goals of Projects in this POI application and housed within the Center for Biologic Imaging (CBI) (www.cbi.pitt.edu) of the University of Pittsburgh. All PL and CL have made, and continue to make, heavy use of the CBI for facility-specific imaging methodologies. Evidence of the longevity of this use is seen in coauthored publications between the members of the Core (Watkins, Beer Stolz, and St. Croix) and Pi's of the individual projects. The formal integration of the CBI into this Program Project will fund the activities of the Core directly related to this Program, thereby ensuring absolute priority and access to all equipment, technical support and training facilities as needed. Furthermore this grant will employ staff within the Core, dedicated solely to the goals of this Program. The value added for integrating this Core into the Program is: ? No user fees or charges for use of the Core. ? Priority access and booking for equipment use. ? Dedicated personnel for this project. ? Open access to all reagent stocks available within the core. ? Direct consultation and interaction with Faculty within the Center

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG043376-01A1
Application #
8598140
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M2))
Project Start
Project End
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$274,738
Indirect Cost
$22,250
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Niedernhofer, L J; Kirkland, J L; Ladiges, W (2016) Molecular pathology endpoints useful for aging studies. Ageing Res Rev :
Robbins, Paul D; Dorronsoro, Akaitz; Booker, Cori N (2016) Regulation of chronic inflammatory and immune processes by extracellular vesicles. J Clin Invest 126:1173-80
Zhang, Changqing; Ferrari, Ricardo; Beezhold, Kevin et al. (2016) Arsenic Promotes NF-Κb-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function. Stem Cells 34:732-42
Ivanisevic, Julijana; Stauch, Kelly L; Petrascheck, Michael et al. (2016) Metabolic drift in the aging brain. Aging (Albany NY) 8:1000-20
Zhu, Yi; Tchkonia, Tamara; Fuhrmann-Stroissnigg, Heike et al. (2016) Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell 15:428-35
Flores, Rafael R; Kim, Eun; Zhou, Liqiao et al. (2015) IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice. Eur J Immunol 45:3114-25
Wallace, Callen T; St Croix, Claudette M; Watkins, Simon C (2015) Data management and archiving in a large microscopy-and-imaging, multi-user facility: Problems and solutions. Mol Reprod Dev 82:630-4
Kelley, Eric E (2015) Dispelling dogma and misconceptions regarding the most pharmacologically targetable source of reactive species in inflammatory disease, xanthine oxidoreductase. Arch Toxicol 89:1193-207
Reay, Daniel P; Bastacky, Sheldon I; Wack, Kathryn E et al. (2015) D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity. Mol Med 21:442-52
Mu, Xiaodong; Tang, Ying; Lu, Aiping et al. (2015) The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy. Hum Mol Genet 24:2923-37

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