The Imaging Core C is comprised of a centralized cutting-edge microscopy facility, absolutely essential to the research goals of Projects in this POI application and housed within the Center for Biologic Imaging (CBI) ( of the University of Pittsburgh. All PL and CL have made, and continue to make, heavy use of the CBI for facility-specific imaging methodologies. Evidence of the longevity of this use is seen in coauthored publications between the members of the Core (Watkins, Beer Stolz, and St. Croix) and Pi's of the individual projects. The formal integration of the CBI into this Program Project will fund the activities of the Core directly related to this Program, thereby ensuring absolute priority and access to all equipment, technical support and training facilities as needed. Furthermore this grant will employ staff within the Core, dedicated solely to the goals of this Program. The value added for integrating this Core into the Program is: ? No user fees or charges for use of the Core. ? Priority access and booking for equipment use. ? Dedicated personnel for this project. ? Open access to all reagent stocks available within the core. ? Direct consultation and interaction with Faculty within the Center

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-2 (M2))
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Scripps Research Institute
La Jolla
United States
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Kelley, Eric E; Baust, Jeff; Bonacci, Gustavo et al. (2014) Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovasc Res 101:352-63
Robbins, Paul D; Morelli, Adrian E (2014) Regulation of immune responses by extracellular vesicles. Nat Rev Immunol 14:195-208
Fu, Lijuan; Guerrero, Candace R; Zhong, Na et al. (2014) Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J Am Chem Soc 136:11582-5
Lu, Aiping; Poddar, Minakshi; Tang, Ying et al. (2014) Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice. Hum Mol Genet 23:4786-800
Vaezi, Alec E; Bepler, Gerold; Bhagwat, Nikhil R et al. (2014) Choline phosphate cytidylyltransferase-? is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer 120:1898-907
Takayama, Koji; Kawakami, Yohei; Lee, Sahnghoon et al. (2014) Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 32:1326-32
Fox, Ira J; Daley, George Q; Goldman, Steven A et al. (2014) Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science 345:1247391