The Statistical Core supports the Projects by providing the data management and analytical services described in the Aims below. Broadly, our goals are to facilitate and ensure accuracy, cost efficiency and appropriate interpretation in the achievement of the scientific aims from each Project. Statistical Core leader Dr. Amalia Magaret has 9 years of experience planning and analyzing studies of herperviruses as well as designing derivative statistical methodology. Data manager Stacy Selke developed the data management procedures which have facilitated collection, quality assurance and sharing of laboratory and clinical data between POI Projects and Cores for 25 years. In the recent cycle. Dr. Joshua Schiffer has developed mathematical models deepening our understanding of the mechanisms influencing viral shedding and the role of the host immune response in containing the virus in the mucosa. Our team is integral to the scientific aims of this POI through our familiarity with the large store of data amassed by our clinic, our established relationships, and our collective experience in HSV research.
Our aims are:
Aim 1 : Consult in the design of experimental methods, including sample size computation, and the conceptualization of Viral dynamics studies.
Aim 2 : Coordinate data management, overseeing data collection procedures, laboratory sample management, results handling and integration of diverse data sources.
Aim 3 : Perform appropriate statistical analyses and modeling, contributing to the interpretation and reporting of results.
Aim 4 : Design novel dynamical mathematical models and other statistical methodologies as needed, optimizing our analytic approach.

Public Health Relevance

The Statistical Core assists all Projects by helping the investigators plan, carry out and analyze their findings using appropriate methods. Our contribution helps ensure that the Specific Aims of each Project include the correct number of participants and samples, and that the subsequent scientific evidence is represented, interpreted and disseminated accurately

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-LR-M)
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University of Washington
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Magaret, Amalia S; Mujugira, Andrew; Hughes, James P et al. (2016) Effect of Condom Use on Per-act HSV-2 Transmission Risk in HIV-1, HSV-2-discordant Couples. Clin Infect Dis 62:456-61
Oseso, Linda; Magaret, Amalia S; Jerome, Keith R et al. (2016) Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection. Sex Transm Dis 43:566-71
Magaret, A; Dong, L; John, M et al. (2016) HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions. Genes Immun 17:412-418
Jing, Lichen; Laing, Kerry J; Dong, Lichun et al. (2016) Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses. J Immunol 196:2205-18
Manguro, Griffins O; Masese, Linnet N; Deya, Ruth W et al. (2016) Genital HSV Shedding among Kenyan Women Initiating Antiretroviral Therapy. PLoS One 11:e0163541
Ramchandani, Meena; Kong, Marlene; Tronstein, Elizabeth et al. (2016) Herpes Simplex Virus Type 1 Shedding in Tears and Nasal and Oral Mucosa of Healthy Adults. Sex Transm Dis 43:756-760
Milman, Neta; Zhu, Jia; Johnston, Christine et al. (2016) In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation. J Infect Dis 214:23-31
Tjernlund, Annelie; Burgener, Adam; Lindvall, Jessica M et al. (2016) In Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8+ T cells--A Tool to Interrogate a Functional Immune Response Ex Vivo. PLoS One 11:e0149907
Nason, Martha C; Patel, Eshan U; Kirkpatrick, Allison R et al. (2016) Immunological Signaling During Herpes Simplex Virus-2 and Cytomegalovirus Vaginal Shedding After Initiation of Antiretroviral Treatment. Open Forum Infect Dis 3:ofw073
Bender Ignacio, Rachel A; Goldman, Jason D; Magaret, Amalia S et al. (2016) Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons. Infect Agent Cancer 11:7

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