The Administrative Core is responsible for the overall administration of the POI.
Our Specific Aims of the Core is to ensure that: 1) the research teams function efficiently using administrative, fiscal and scientific review procedures;2) the investigators are adherent to all pertinent regulatory practices and guidelines and adhere to the highest ethical standards in conducting their research;3)the POI investigators communicate effectively with each other, with the broader scientific and clinical communities, and other collaborators, as well as with the program sponsor, NIH. The Administrative Core coordinates the administrative, fiscal, regulatory and organizational aspects of our herpes simplex virus (HSV) research program to support the activities of the Scientific Leadership Group. Personnel in this Core will facilitate scientific communication among the clinical and laboratory sites of the projects and the investigators and staff involved in the scientific and core projects. They will prepare, oversee and maintain the IRB applications for all projects and cores;will provide fixed support services to each of the Projects and Cores;and will supervise the transport of specimens both locally and internationally to the laboratories involved in the projects. These activities involve scientific and administrative staff and facilities of the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, WA, and the Kenyatta National Hospital in Kenya. Administrative staff members in the Program bridge these institutions and have ample experience coordinating international studies. The Administrafive Core will also facilitate meetings within the POI as well as coordinate input from the Local and External Advisory Committees.

Public Health Relevance

The Administrative Core will help the scientists in organizing the research activities, tracking the expenses, making sure that the research is conducted ethically, and that we have input from scientists in other institutions to make sure we achieve our goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI030731-24
Application #
8696996
Study Section
Special Emphasis Panel (ZAI1-LR-M)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
24
Fiscal Year
2014
Total Cost
$253,281
Indirect Cost
$89,345
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Magaret, Amalia S; Mujugira, Andrew; Hughes, James P et al. (2016) Effect of Condom Use on Per-act HSV-2 Transmission Risk in HIV-1, HSV-2-discordant Couples. Clin Infect Dis 62:456-61
Oseso, Linda; Magaret, Amalia S; Jerome, Keith R et al. (2016) Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection. Sex Transm Dis 43:566-71
Magaret, A; Dong, L; John, M et al. (2016) HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions. Genes Immun 17:412-418
Jing, Lichen; Laing, Kerry J; Dong, Lichun et al. (2016) Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses. J Immunol 196:2205-18
Manguro, Griffins O; Masese, Linnet N; Deya, Ruth W et al. (2016) Genital HSV Shedding among Kenyan Women Initiating Antiretroviral Therapy. PLoS One 11:e0163541
Ramchandani, Meena; Kong, Marlene; Tronstein, Elizabeth et al. (2016) Herpes Simplex Virus Type 1 Shedding in Tears and Nasal and Oral Mucosa of Healthy Adults. Sex Transm Dis 43:756-760
Milman, Neta; Zhu, Jia; Johnston, Christine et al. (2016) In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation. J Infect Dis 214:23-31
Tjernlund, Annelie; Burgener, Adam; Lindvall, Jessica M et al. (2016) In Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8+ T cells--A Tool to Interrogate a Functional Immune Response Ex Vivo. PLoS One 11:e0149907
Nason, Martha C; Patel, Eshan U; Kirkpatrick, Allison R et al. (2016) Immunological Signaling During Herpes Simplex Virus-2 and Cytomegalovirus Vaginal Shedding After Initiation of Antiretroviral Treatment. Open Forum Infect Dis 3:ofw073
Bender Ignacio, Rachel A; Goldman, Jason D; Magaret, Amalia S et al. (2016) Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons. Infect Agent Cancer 11:7

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