Dengue virus (DENV) infections are an emerging problem, causing disease in tropical and subtropical countries, including the U.S, with recent outbreaks in Texas, Hawaii and Florida. An increase in the average age of DENV related hospitalizations has been globally recognized with adult disease more commonly recognized, but prospective clinical studies that characterize dengue illness in both children and adults are lacking. Dengue hemorrhagic fever (DHF), a more severe clinical manifestation of DENV infection, has been classified by the WHO into four grades of severity with minimal criteria of capillary leakage and thrombocytopenia. The WHO released revised guidelines for the diagnosis of

Public Health Relevance

Dengue virus (DENV) infections are an emerging problem world-wide with several recent introductions of disease into the US. DENV infection can cause severe illness and shock, but early identification of individuals who will develop severe disease is currently lacking. Better modalities for early identification and management guidance in children and adults with DENV infection would have a significant impact on global health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI034533-21
Application #
8495658
Study Section
Special Emphasis Panel (ZAI1-KP-M (J3))
Project Start
Project End
Budget Start
2013-07-18
Budget End
2014-06-30
Support Year
21
Fiscal Year
2013
Total Cost
$465,577
Indirect Cost
$68,294
Name
University of Rhode Island
Department
Type
DUNS #
144017188
City
Kingston
State
RI
Country
United States
Zip Code
02881
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Anderson, Kathryn B; Gibbons, Robert V; Cummings, Derek A T et al. (2014) A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand. J Infect Dis 209:360-8

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