In previous worl

Public Health Relevance

This project examines mechanisms of tolerance induction versus activation of self-antigen-specific CDS T cells in autoimmune disease. Innovative technologies developed by this Program will be used to explore novel concepts regarding the roles of CDS T cells in diabetes, and the findings will contribute to development of better approaches for preventing or treating autoimmune diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI035296-20A1
Application #
8592231
Study Section
Special Emphasis Panel (ZAI1-LAR-I (M1))
Project Start
Project End
Budget Start
2013-05-15
Budget End
2014-04-30
Support Year
20
Fiscal Year
2013
Total Cost
$346,907
Indirect Cost
$118,679
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Hogquist, Kristin A; Jameson, Stephen C (2014) The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Nat Immunol 15:815-23
Klein, Ludger; Kyewski, Bruno; Allen, Paul M et al. (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 14:377-91
Dunmire, Samantha K; Odumade, Oludare A; Porter, Jean L et al. (2014) Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. PLoS One 9:e85422
Balfour Jr, Henry H; Odumade, Oludare A; Schmeling, David O et al. (2013) Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis 207:80-8
Pauken, Kristen E; Linehan, Jonathan L; Spanier, Justin A et al. (2013) Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. J Immunol 191:4913-7
Stritesky, Gretta L; Xing, Yan; Erickson, Jami R et al. (2013) Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A 110:4679-84
Gerner, Michael Y; Heltemes-Harris, Lynn M; Fife, Brian T et al. (2013) Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control. J Immunol 191:1011-5
Martinez, Ryan J; Zhang, Na; Thomas, Stephanie R et al. (2012) Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol 188:170-81
Mueller, Daniel L (2010) Mechanisms maintaining peripheral tolerance. Nat Immunol 11:21-7
Curtsinger, Julie M; Mescher, Matthew F (2010) Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol 22:333-40

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