The Administrafive Core will support all ofthe projects and Core B (Autoimmune Mouse Core) by providing oversight, support and scientific review ofthe Program. The administrative team includes Drs. Mescher (director) and Jenkins (associate director) and Ms. Bethke (administrafive assistant).
The Specific Aims of this Core are:
Specific Aim 1. To provide administrative and budgetary oversight ofthe Program. This includes regular review of grant funds expenditures Specific Aim 2. To provide administrative and clerical support to project invesfigators and Core B. The Core will support the individual project invesfigators and Core B in all administrative aspects related to the Program research.
Specific Aim 3. To provide oversight and review of scienfific progress and direcfions. This will be accomplished, in part, through regularly scheduled meefings ofthe Program invesfigators, and in part through review of the Program by an external Advisory Panel. The director will be responsible for budgetary oversight ofthe Program, and the director and associate director will be jointly responsible for providing oversight of the scienfific progress and directions of the projects and Program. All ofthe investigators ofthe Program are housed in the Center for Immunology, and adequate office space and equipment, including computers, are available to the Administrative Core within the Center for Immunology.

Public Health Relevance

(See Instructions): The Administrafive Core will provide budgetary and scientific oversight and support to all four projects and Core B. Autoimmune Mouse Core.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-LAR-I (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
United States
Zip Code
Malhotra, Deepali; Linehan, Jonathan L; Dileepan, Thamotharampillai et al. (2016) Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol 17:187-95
Beura, Lalit K; Hamilton, Sara E; Bi, Kevin et al. (2016) Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532:512-6
Kalekar, Lokesh A; Schmiel, Shirdi E; Nandiwada, Sarada L et al. (2016) CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nat Immunol 17:304-14
Xing, Yan; Wang, Xiaodan; Jameson, Stephen C et al. (2016) Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling. Nat Immunol 17:565-73
Martinov, Tijana; Spanier, Justin A; Pauken, Kristen E et al. (2016) PD-1 pathway-mediated regulation of islet-specific CD4(+) T cell subsets in autoimmune diabetes. Immunoendocrinology (Houst) 3:
Pritchard, Gretchen Harms; Cross, Eric W; Strobel, Marjorie et al. (2016) Spontaneous partial loss of the OT-I transgene. Nat Immunol 17:471
Grimm, Jennifer M; Schmeling, David O; Dunmire, Samantha K et al. (2016) Prospective studies of infectious mononucleosis in university students. Clin Transl Immunology 5:e94
Schmiel, Shirdi E; Yang, Jessica A; Jenkins, Marc K et al. (2016) Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination. J Immunol :
Spanier, Justin A; Frederick, Daniel R; Taylor, Justin J et al. (2016) Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment. Nat Commun 7:11804
Manlove, Luke S; Berquam-Vrieze, Katherine E; Pauken, Kristen E et al. (2015) Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol 195:4028-37

Showing the most recent 10 out of 122 publications