This program project has assembled molecular biologist, immunologist, population geneticist and clinical scientist to investigate the mechanism of co-stimulatory responses in patients with MS and type 1 diabetes, and examine the hypothesis that a genetic predisposition for alterations in co-stimulatory signal leads to heightened inflammatory responses that in part underlies the pathophysiology of autoimmune diseases. To accomplish these goals, an administrative core is requested to ensure that financial activities among project participants are in compliance with the appropriate NIH policies and guidelines throughout the project period and to facilitate the report of our findings on an annual basis to the NIH. Additionally, an important function of the administrative core will be the arrangement of monthly conference calls among the PPG participants and arranging the bi-annual meetings of the advisory board. Thus funding the administrative core is important to accomplish the goals of the PPG.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI039671-19
Application #
8700304
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
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Kurtulus, Sema; Sakuishi, Kaori; Ngiow, Shin-Foong et al. (2015) TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest 125:4053-62
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Preusser, Matthias; Lim, Michael; Hafler, David A et al. (2015) Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nat Rev Neurol 11:504-14

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