This program project has assembled molecular biologist, immunologist, population geneticist and clinical scientist to investigate the mechanism of co-stimulatory responses in patients with MS and type 1 diabetes, and examine the hypothesis that a genetic predisposition for alterations in co-stimulatory signal leads to heightened inflammatory responses that in part underlies the pathophysiology of autoimmune diseases. To accomplish these goals, an administrative core is requested to ensure that financial activities among project participants are in compliance with the appropriate NIH policies and guidelines throughout the project period and to facilitate the report of our findings on an annual basis to the NIH. Additionally, an important function of the administrative core will be the arrangement of monthly conference calls among the PPG participants and arranging the bi-annual meetings of the advisory board. Thus funding the administrative core is important to accomplish the goals of the PPG.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01AI039671-19
Application #
8700304
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Farh, Kyle Kai-How; Marson, Alexander; Zhu, Jiang et al. (2015) Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518:337-43
Esposito, Laura; Hunter, Kara M D; Clark, Jan et al. (2014) Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles. J Immunol 193:889-900
Stern, Joel N H; Yaari, Gur; Vander Heiden, Jason A et al. (2014) B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Sci Transl Med 6:248ra107
Manzel, Arndt; Muller, Dominik N; Hafler, David A et al. (2014) Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep 14:404
Sage, Peter T; Paterson, Alison M; Lovitch, Scott B et al. (2014) The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity 41:1026-39
Kofler, David M; Marson, Alexander; Dominguez-Villar, Margarita et al. (2014) Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest 124:2513-22
Gautron, Anne-Sophie; Dominguez-Villar, Margarita; de Marcken, Marine et al. (2014) Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells. Eur J Immunol 44:2703-11
Joller, Nicole; Lozano, Ester; Burkett, Patrick R et al. (2014) Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 40:569-81
Kleinewietfeld, Markus; Hafler, David A (2014) Regulatory T cells in autoimmune neuroinflammation. Immunol Rev 259:231-44
Lee, Youjin; Collins, Mary; Kuchroo, Vijay K (2014) Unexpected targets and triggers of autoimmunity. J Clin Immunol 34 Suppl 1:S56-60

Showing the most recent 10 out of 154 publications