Dr. Wucherpfennig has provided scientific and administrative leadership for this PPG since 1999, and this effort has been productive as evidenced by the large number of collaborative publications, many of which have been in high-impact journals. He will continue to closely interact with all members ofthe team to foster collaboration and identify new scientific opportunities. Dr. Wucherpfennig will organize regular formal scientific meetings at which recent progress will be presented and new opportunities for collaboration will be discussed. All project leaders work in the Boston area, Drs. Wucherpfennig, Turtey and Kuchroo on the Harvard Medical School (HMS) campus, and Dr. Love at the Koch Institute of MIT. Drs. Turley and Wucherpfennig are neighbors at the Dana-Farber Cancer Institute, and Drs. Kuchroo, Turtey and Wucherpfennig frequently meet at seminars and as part of the Program for Immunology at HMS. Drs. Kuchroo and Wucherpfennig also jointly teach an annual quarter course on Autoimmunity'for graduate students (since 1999). These frequent interactions foster dialogue and collaboration. In addition. Dr. Wucherpfennig will organize annual meetings with the Scientific Advisory Board (SAB) at which each project leader will present recent progress and discuss directions for the coming year. All members of our SAB work at HMS, and we will therefore also have many opportunities to consult them on an informal basis. Dr. Wucherpfennig will also continue to be in charge of all administrative aspects and will be assisted by this administrator and Dana-Farber grants and financial management specialists.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01AI045757-16
Application #
8705348
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02215
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Fletcher, Anne L; Elman, Jessica S; Astarita, Jillian et al. (2014) Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Sci Transl Med 6:249ra109
Stern, Joel N H; Yaari, Gur; Vander Heiden, Jason A et al. (2014) B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Sci Transl Med 6:248ra107
Manzel, Arndt; Muller, Dominik N; Hafler, David A et al. (2014) Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep 14:404
Choudhuri, Kaushik; LlodrĂ¡, Jaime; Roth, Eric W et al. (2014) Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature 507:118-23
Zhou, Penghui; Shaffer, Donald R; Alvarez Arias, Diana A et al. (2014) In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature 506:52-7
Sollid, Ludvig M; Pos, Wouter; Wucherpfennig, Kai W (2014) Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Curr Opin Immunol 31:24-30
Elpek, Kutlu G; Cremasco, Viviana; Shen, Hua et al. (2014) The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res 2:655-67
Woodruff, Matthew C; Heesters, Balthasar A; Herndon, Caroline N et al. (2014) Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine. J Exp Med 211:1611-21
Kofler, David M; Marson, Alexander; Dominguez-Villar, Margarita et al. (2014) Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest 124:2513-22

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