The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support. To ensure optimal cooperation and communication, the Core will coordinate meetings at least every three weeks among the Program Project members, who are located at Children's Hospital Boston, the Dana Farber Cancer Institute, the CBER/FDA and Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, using Web based media. The Administrative Core takes on added importance because of the geographic distance between the Program Project investigators, and will provide effective communication services. Due to special circumstances, the Administrative Core will also administrate and oversee funds allocated for postdoctoral fellows and supplies to one ofthe collaborators, Dr. Gerardo Kaplan at the CBER/FDA. This administrative activity includes purchasing supplies for the CBER/FDA site, as well as coordinating the hiring of personnel working at the CBER/FDA site, through the Children's Hospital Boston. Children's Hospital Boston and Dale T. Umetsu are responsible for the application and for collaborative research activities described.

Public Health Relevance

The Program Project will focus on inflammatory diseases including asthma and allergy as well as, and study the mechanisms of immune regulation. We will determine how a newly discovered family of genes called TIMs, regulate immune responses that cause these clinical problems. These genes have remarkably novel functions that affect immunity, and could lead to new therapies for asthma, allergy and autoimmunity

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI054456-09
Application #
8507124
Study Section
Special Emphasis Panel (ZAI1-RRS-I)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$156,523
Indirect Cost
$46,144
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Foks, Amanda C; Engelbertsen, Daniel; Kuperwaser, Felicia et al. (2016) Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol 36:456-65
Kim, Hye Young; Umetsu, Dale T; Dekruyff, Rosemarie H (2016) Innate lymphoid cells in asthma: Will they take your breath away? Eur J Immunol 46:795-806
Brauner, Eran; Gunda, Viswanath; Vanden Borre, Pierre et al. (2016) Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer. Oncotarget 7:17194-211
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Echbarthi, Meriem; Zonca, Manuela; Mellwig, Rachel et al. (2015) Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse. Traffic 16:1193-207
Kroy, Daniela C; Ciuffreda, Donatella; Cooperrider, Jennifer H et al. (2014) Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology 146:550-61
Xiao, Yanping; Yu, Sanhong; Zhu, Baogong et al. (2014) RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 211:943-59
Recacha, Rosario; Jiménez, David; Tian, Li et al. (2014) Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions. Acta Crystallogr D Biol Crystallogr 70:1934-43
Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40:542-53

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