The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support. To ensure optimal cooperation and communication, the Core will coordinate meetings at least every three weeks among the Program Project members, who are located at Children's Hospital Boston, the Dana Farber Cancer Institute, the CBER/FDA and Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, using Web based media. The Administrative Core takes on added importance because of the geographic distance between the Program Project investigators, and will provide effective communication services. Due to special circumstances, the Administrative Core will also administrate and oversee funds allocated for postdoctoral fellows and supplies to one ofthe collaborators, Dr. Gerardo Kaplan at the CBER/FDA. This administrative activity includes purchasing supplies for the CBER/FDA site, as well as coordinating the hiring of personnel working at the CBER/FDA site, through the Children's Hospital Boston. Children's Hospital Boston and Dale T. Umetsu are responsible for the application and for collaborative research activities described.

Public Health Relevance

The Program Project will focus on inflammatory diseases including asthma and allergy as well as, and study the mechanisms of immune regulation. We will determine how a newly discovered family of genes called TIMs, regulate immune responses that cause these clinical problems. These genes have remarkably novel functions that affect immunity, and could lead to new therapies for asthma, allergy and autoimmunity

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01AI054456-11
Application #
8866347
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Kroy, Daniela C; Ciuffreda, Donatella; Cooperrider, Jennifer H et al. (2014) Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology 146:550-61
Xiao, Yanping; Yu, Sanhong; Zhu, Baogong et al. (2014) RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 211:943-59
Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40:542-53
Recacha, Rosario; Jiménez, David; Tian, Li et al. (2014) Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions. Acta Crystallogr D Biol Crystallogr 70:1934-43
Gubin, Matthew M; Zhang, Xiuli; Schuster, Heiko et al. (2014) Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515:577-81
Kim, Hye Young; Chang, Ya-Jen; Chuang, Ya-Ting et al. (2013) T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol 132:414-25.e6
Albacker, L A; Yu, S; Bedoret, D et al. (2013) TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol 6:580-90
Jemielity, Stephanie; Wang, Jinyize J; Chan, Ying Kai et al. (2013) TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog 9:e1003232
Manangeeswaran, Mohanraj; Jacques, Jerome; Tami, Cecilia et al. (2012) Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans. Gastroenterology 142:1516-25.e3
Kim, Hye Young; Eyheramonho, Maria Belen; Pichavant, Muriel et al. (2011) A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest 121:1111-8

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