The Administrative Core is directed by Dr. Dennis W. Metzger, Program Project Director. The Core Facility fosters completion of the research project specific aims, provides statistical analysis of data and supports effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations into the mucosal immunopathogenesis of F. tularensis. The Core provides statistical analysis of experimental design and interpretation of results, administrative support, and fiscal management. An Executive Committee consisting of the Program Director and the subproject Project Leaders and Core Directors (Drs. Gosselin, Hazlett, Melendez, Metzger, and Sellati) meet twice monthly to review progress in the subprojects and to address any concerns or problems. An External Scientific Advisory Board, consisting of Drs. J. Wayne Conlan, Martha Furie, Lester Kobzik, Kathleen McDonough, and Anders Sjostedt, reviews results obtained in the subprojects and meets annually on site to review the program objectives and progress.

Public Health Relevance

This Core Facility will foster completion of the research project specific aims, provide statistical analysis of data and support effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI056320-09
Application #
8698576
Study Section
Special Emphasis Panel (ZAI1-LR-M (S1))
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$135,520
Indirect Cost
$47,924
Name
Albany Medical College
Department
Type
DUNS #
190592162
City
Albany
State
NY
Country
United States
Zip Code
12208
Periasamy, Sivakumar; Avram, Dorina; McCabe, Amanda et al. (2016) An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. PLoS Pathog 12:e1005517
Sunagar, Raju; Kumar, Sudeep; Franz, Brian J et al. (2016) Tularemia vaccine development: paralysis or progress? Vaccine (Auckl) 6:9-23
McCarthy, Donald A; Nazem, Ahmad A; McNeilan, James et al. (2016) Nanoenhanced matrix metalloproteinase-responsive delivery vehicles for disease resolution and imaging. Exp Biol Med (Maywood) :
Sunagar, Raju; Kumar, Sudeep; Franz, Brian J et al. (2016) Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice. Vaccine 34:3396-404
Rabadi, Seham M; Sanchez, Belkys C; Varanat, Mrudula et al. (2016) Antioxidant Defenses of Francisella tularensis Modulate Macrophage Function and Production of Proinflammatory Cytokines. J Biol Chem 291:5009-21
Duffy, Ellen B; Periasamy, Sivakumar; Hunt, Danielle et al. (2016) FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. J Leukoc Biol 100:1335-1347
Shakerley, Nicole L; Chandrasekaran, Akshaya; Trebak, Mohamed et al. (2016) Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity. J Biol Chem 291:3871-81
Franz, Brian J; Li, Ying; Bitsaktsis, Constantine et al. (2015) Downmodulation of vaccine-induced immunity and protection against the intracellular bacterium Francisella tularensis by the inhibitory receptor FcγRIIB. J Immunol Res 2015:840842
Bitsaktsis, Constantine; Babadjanova, Zulfia; Gosselin, Edmund J (2015) In vivo mechanisms involved in enhanced protection utilizing an Fc receptor-targeted mucosal vaccine platform in a bacterial vaccine and challenge model. Infect Immun 83:77-89
Suresh, Ragavan Varadharajan; Ma, Zhuo; Sunagar, Raju et al. (2015) Preclinical testing of a vaccine candidate against tularemia. PLoS One 10:e0124326

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