The Administrative Core is directed by Dr. Dennis W. Metzger, Program Project Director. The Core Facility fosters completion of the research project specific aims, provides statistical analysis of data and supports effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations into the mucosal immunopathogenesis of F. tularensis. The Core provides statistical analysis of experimental design and interpretation of results, administrative support, and fiscal management. An Executive Committee consisting of the Program Director and the subproject Project Leaders and Core Directors (Drs. Gosselin, Hazlett, Melendez, Metzger, and Sellati) meet twice monthly to review progress in the subprojects and to address any concerns or problems. An External Scientific Advisory Board, consisting of Drs. J. Wayne Conlan, Martha Furie, Lester Kobzik, Kathleen McDonough, and Anders Sjostedt, reviews results obtained in the subprojects and meets annually on site to review the program objectives and progress.
This Core Facility will foster completion of the research project specific aims, provide statistical analysis of data and support effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations.
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|Pham, Giang H; Iglesias, Bibiana V; Gosselin, Edmund J (2014) Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells. Vaccine 32:5212-20|
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|Ma, Zhuo; Banik, Sukalyani; Rane, Harshita et al. (2014) EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice. Mol Microbiol 91:976-95|
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|Mahawar, Manish; Rabadi, Seham M; Banik, Sukalyani et al. (2013) Identification of a live attenuated vaccine candidate for tularemia prophylaxis. PLoS One 8:e61539|
|Metzger, Dennis W; Salmon, Sharon L; Kirimanjeswara, Girish (2013) Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection. Infect Immun 81:2022-7|
|Iglesias, Bibiana V; Bitsaktsis, Constantine; Pham, Giang et al. (2013) Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen. Immunol Cell Biol 91:139-48|
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