Core C has overall responsible for the organizational structure and progress of this Program Project. Dr Cunningham-Rundles works with each of the Program Leaders, the Administrators and the external Advisory Board (see below) to monitor the progress of each, and help define new directions. The Pis and sub investigators meet monthly face to face, or more often if needed, to discuss ongoing collaborations, share materials, discuss new data and refine techniques. The group reviews also all aspects of this program as a whole and the progress of each Project. This includes assessing the nature of the interactions between Projects and use of the Patient Core A, Cell and Tissue Core B, and Administrative Core C. An important part of these meetings is to find materials or resources that are needed to facilitate collaborations. Other investigators at Mount Sinai and post-doctoral fellows attend the face to face meeting, in order to provide input into novel techniques, approaches and limitations of such endeavors. This keeps the investigators aware of the potential advances of each Project, and aware of new methods available in the Cores. General discussions between all of the members involved in the Program Project Grant foster additional interactions, technically as well as intellectually. Core C organizes a Scientific meeting with the External Advisory Board, which reviews and critiques the project as a whole and advises the Project leaders and the PI as to areas where improvements can be made.

Public Health Relevance

The administrative Core C of this Program Project grant supplies the administrative infrastructure needed to keep the work of investigators, post doctoral fellows, students, participating physicians and nursing staff well coordinated. This Core is in continuous contact with each project to monitor all expenses, review budgets, pay for pertinent materials, organize monthly meetings of Project leaders, organize the Symposium, and arrange visits and meetings with the external Advisory Board.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI061093-10
Application #
8525310
Study Section
Special Emphasis Panel (ZAI1-PA-I)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2013
Total Cost
$60,255
Indirect Cost
$14,208
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Gaschignard, Jean; Levy, Corinne; Chrabieh, Maya et al. (2014) Invasive pneumococcal disease in children can reveal a primary immunodeficiency. Clin Infect Dis 59:244-51
Gutzeit, Cindy; Nagy, Noemi; Gentile, Maurizio et al. (2014) Exosomes derived from Burkitt's lymphoma cell lines induce proliferation, differentiation, and class-switch recombination in B cells. J Immunol 192:5852-62
Maglione, Paul J; Ko, Huaibin M; Beasley, Mary B et al. (2014) Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency. J Allergy Clin Immunol 133:535-42
Castiello, Maria Carmina; Bosticardo, Marita; Pala, Francesca et al. (2014) Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. J Autoimmun 50:42-50
Al-Herz, Waleed; Bousfiha, Aziz; Casanova, Jean-Laurent et al. (2014) Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol 5:162
Magri, Giuliana; Miyajima, Michio; Bascones, Sabrina et al. (2014) Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol 15:354-64
Maglione, Paul J; Overbey, Jessica R; Radigan, Lin et al. (2014) Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. Ann Allergy Asthma Immunol 113:452-9
Keller, M; Glessner, J; Resnick, E et al. (2014) Burden of copy number variation in common variable immunodeficiency. Clin Exp Immunol 177:269-71
Gutzeit, Cindy; Magri, Giuliana; Cerutti, Andrea (2014) Intestinal IgA production and its role in host-microbe interaction. Immunol Rev 260:76-85
Menard, Laurence; Cantaert, Tineke; Chamberlain, Nicolas et al. (2014) Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol 133:1149-61

Showing the most recent 10 out of 70 publications