CORE A: Patient Care Core The purpose of Core A is to coordinate and facilitate all the patient based research in this Program Project, arranging for patients to have selected tests at intervals that maximizes research testing while not disrupting the clinical care of any subject. This Core is responsible for arranging with patients convenient dates for appointments for clinical care, and organizing any research blood testing and obtaining samples for the laboratories of the participating investigators. Core A also coordinates the visits of patients pertinent to this program, who are traveling to Rockefeller Hospital so that blood or other samples can be shared with the investigative team. This Core also arranges for the submission of cells or other materials obtained, to the facilities of Core B, for cell phenotyping and/or cell isolation, and the establishment of cell lines as needed. This Core is responsible for obtaining cells, or other patient materials from outside sources as needed. This Core is also responsible for maintaining and updating all IRB and HIPAA materials and to obtain patient consents for all procedures. This Core will therefore continue to support Projects 1-4 in this ongoing Program Project.

Public Health Relevance

Patient Core A is required to coordinate patient recruitment while not impeding clinical care, so that research work is carried out under correct IRB protocols, confidentiality is maintained, and Project Leaders and other involved investigators and laboratories are aware of patients coming for clinic visits in a timely manner. Core A coordinates the collection of all materials obtained during clinic visits, or that are shipped, with Core B in a de-identified manner, in order to maximize'the use of all samples

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PA-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
New York
United States
Zip Code
Casanova, Jean-Laurent; Abel, Laurent (2017) Human genetics of infectious diseases: Unique insights into immunological redundancy. Semin Immunol :
Boisson, Bertrand; Puel, Anne; Picard, Capucine et al. (2017) Human I?B? Gain of Function: a Severe and Syndromic Immunodeficiency. J Clin Immunol 37:397-412
Gernez, Yael; Freeman, Alexandra F; Holland, Steven M et al. (2017) Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. J Allergy Clin Immunol Pract :
Schickel, Jean-Nicolas; Glauzy, Salomé; Ng, Yen-Shing et al. (2017) Self-reactive VH4-34-expressing IgG B cells recognize commensal bacteria. J Exp Med 214:1991-2003
Perkins, Tiffany; Rosenberg, Jacob M; Le Coz, Carole et al. (2017) Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies. J Allergy Clin Immunol Pract 5:1344-1350.e3
Ma, Chi A; Stinson, Jeffrey R; Zhang, Yuan et al. (2017) Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet 49:1192-1201
Magri, Giuliana; Comerma, Laura; Pybus, Marc et al. (2017) Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals. Immunity 47:118-134.e8
Albin-Leeds, Stephanie; Ochoa, Juliana; Mehta, Harshna et al. (2017) Idiopathic T cell lymphopenia identified in New York State Newborn Screening. Clin Immunol 183:36-40
Di Niro, R; Snir, O; Kaukinen, K et al. (2016) Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunol 9:254-64
Scott, Eric M; Halees, Anason; Itan, Yuval et al. (2016) Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery. Nat Genet 48:1071-6

Showing the most recent 10 out of 153 publications