Core C has overall responsible for the organizational structure and progress of this Program Project. Dr Cunningham-Rundles works with each of the Program Leaders, the Administrators and the external Advisory Board (see below) to monitor the progress of each, and help define new directions. The Pis and sub investigators meet monthly face to face, or more often if needed, to discuss ongoing collaborations, share materials, discuss new data and refine techniques. The group reviews also all aspects of this program as a whole and the progress of each Project. This includes assessing the nature of the interactions between Projects and use of the Patient Core A, Cell and Tissue Core B, and Administrative Core C. An important part of these meetings is to find materials or resources that are needed to facilitate collaborations. Other investigators at Mount Sinai and post-doctoral fellows attend the face to face meeting, in order to provide input into novel techniques, approaches and limitations of such endeavors. This keeps the investigators aware of the potential advances of each Project, and aware of new methods available in the Cores. General discussions between all of the members involved in the Program Project Grant foster additional interactions, technically as well as intellectually. Core C organizes a Scientific meeting with the External Advisory Board, which reviews and critiques the project as a whole and advises the Project leaders and the PI as to areas where improvements can be made.
The administrative Core C of this Program Project grant supplies the administrative infrastructure needed to keep the work of investigators, post doctoral fellows, students, participating physicians and nursing staff well coordinated. This Core is in continuous contact with each project to monitor all expenses, review budgets, pay for pertinent materials, organize monthly meetings of Project leaders, organize the Symposium, and arrange visits and meetings with the external Advisory Board.
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|Chorny, Alejo; Casas-Recasens, Sandra; Sintes, Jordi et al. (2016) The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. J Exp Med 213:2167-85|
|Massaad, Michel J; Zhou, Jia; Tsuchimoto, Daisuke et al. (2016) Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest 126:4219-4236|
|Scott, Eric M; Halees, Anason; Itan, Yuval et al. (2016) Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery. Nat Genet 48:1071-6|
|Cols, Montserrat; Rahman, Adeeb; Maglione, Paul J et al. (2016) Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. J Allergy Clin Immunol 137:1206-1215.e6|
|Lee, Alison Joanne; Moncada-VÃ©lez, Marcela; Picard, Capucine et al. (2016) Severe Mycobacterial Diseases in a Patient with GOF IÎºBÎ± Mutation Without EDA. J Clin Immunol 36:12-5|
|Cantaert, Tineke; Schickel, Jean-Nicolas; Bannock, Jason M et al. (2016) Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint. J Clin Invest 126:4289-4302|
|Kuehn, Hye Sun; Boisson, Bertrand; Cunningham-Rundles, Charlotte et al. (2016) Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. N Engl J Med 374:1032-43|
|Bonilla, Francisco A; Barlan, Isil; Chapel, Helen et al. (2016) International Consensus Document (ICON): Common Variable Immunodeficiency Disorders. J Allergy Clin Immunol Pract 4:38-59|
|Morbach, Henner; Schickel, Jean-Nicolas; Cunningham-Rundles, Charlotte et al. (2016) CD19 controls Toll-like receptor 9 responses in human BÂ cells. J Allergy Clin Immunol 137:889-898.e6|
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