The Administrative Core (Admin) will function as the organizational structure that coordinates the activities of the P01, facilitating its scientific mission and external evaluation and promoting synergy with UTMB research programs. Day-to-day operations of Admin are directed by Dr. Allan Brasier, an experienced and productive leader who brings considerable leveraging strength to facilitate the P01?s research mission. In situations when Dr. Brasier is unavailable or unable to provide oversight to the program, Dr. Garofalo will assume leadership of the Admin Core. The major goals of Admin are to assist the Project Leaders (PLs) and Core Directors by: 1) Promoting Project Interactions and Synergy. To ensure continuing productive interactions among the research projects (RPs) and scientific alignment to the central theme of this P01, Admin coordinates twice- monthly research-in-progress meetings and quarterly business meetings. Admin monitors expenditures, will reallocate resources as necessary, and will facilitate resolution of any conflicts that might arise during the conduct of these studies. Admin will further promote inter-project communication and assist in facilitating research design, statistical analysis and data management for all three RPs. 2) Providing Statistical Analysis and Data Management. Dr. Heidi Spratt, a PhD-trained biostatistician with relevant experience in multivariate statistics, will collaborate with all three RPs on statistical aspects of experimental and clinical study design, power calculations, and data analysis. 3) Serving as the Single Point of Contact to the NIAID and the UTMB Office of Sponsored Programs. Admin will be responsible for ensuring appropriate compliance with all policies, laws, and regulations of UTMB, the State of Texas, NIH, and the NIAID, as well as reporting, and fiscal management of the P01 and its projects, including submitting the documentation and project reports required by the NIAID. 4) Coordinating P01 External Reviews. Admin will facilitate site visits with the NIAID Project Officer, Internal Advisory Committee (IAC), and External Advisory Committee (EAC), fulfilling their missions and communicating their recommendations to the NIH PO and the P01 PLs. As co-PI of this P01, the Director of Admin will assume responsibility for implementing these recommendations. 5. Integrating P01 RPs with ongoing asthma-related research in UTMB centers and institutes. The Admin Director will ensure ongoing integration of the P01 with other major UTMB research entities, including Departments, Centers, and Institutes to coordinate research projects and develop new ones. In the most recent project period, these entities have been a major source of intellectual and resource support and have significantly advanced the goals of this P01. By performing these functions, Admin will help to ensure continued efforts towards programmatic goals, facilitate internal and external communications, and relieve project leaders of burdensome administrative activities. This will free the project and core leaders to pursue their scientific tasks and objectives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI062885-11
Application #
9573991
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-07-20
Budget End
2019-06-30
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Texas Med Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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Ba, Xueqing; Boldogh, Istvan (2018) 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions. Redox Biol 14:669-678
Visnes, Torkild; Cázares-Körner, Armando; Hao, Wenjing et al. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362:834-839
Ochoa, Lorenzo F; Kholodnykh, Alexander; Villarreal, Paula et al. (2018) Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep 8:13348
Liu, Zhiqing; Tian, Bing; Chen, Haiying et al. (2018) Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem 151:450-461
Bao, Xiaoyong; Kolli, Deepthi; Esham, Dana et al. (2018) Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells. Viruses 10:
Chahar, Harendra Singh; Corsello, Tiziana; Kudlicki, Andrzej S et al. (2018) Respiratory Syncytial Virus Infection Changes Cargo Composition of Exosome Released from Airway Epithelial Cells. Sci Rep 8:387
Hosoki, Koa; Rajarathnam, Krishna; Sur, Sanjiv (2018) Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor. Clin Exp Allergy :
Tian, Bing; Widen, Steven G; Yang, Jun et al. (2018) The NF?B subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells. J Biol Chem 293:16528-16545
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100

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