The purpose of Core A is to ensure scientific progress by providing adequate scientific and administrative leadership to the program and provide adequate financial oversight. This will be accomplished by extensive review of scientific progress during monthly meetings of all the lab groups and smaller meetings held by subgroups. Scientific direction and research results will be subject to intense, yet constructive, criticism by investigators within the P01, and by an outside advisory board. We strongly believe that our extensive collaborative approach promoted by Core A is unique. Indeed, this program represents the nucleating group for Bay Area investigators studying intracellular pathogens and innate immunity.
The Specific Aims are: 1. Ensure Scientific Progress, and II. Implement Financial Management and Administrative Support. To facilitate interactions among investigators, two-hour joint lab meetings will continue to be held monthly at the UCSF Mission Bay Campus. The monthly meetings consist of introductory discussions, two scientific presentations, and post-meeting discussions. A scientific advisory board will be maintained to oversee research progress and provide objective criticism of the programs. The board will meet once every other year and provide a report. To facilitate interactions between the cores and the projects, each of the labs will designate representative to Core B (mouse and ENU core). A website will help coordinate sharing of data, protocols, and Powerpoint presentations from the monthly meeting. Additional mechanisms to promote interactions include shared interviews of potential post-doctoral fellows and a joint seminar program between UCB and UCSF. Core A will provide the financial oversight for the program project and for each research plan and core. UC Berkeley will act as the central administrator of the program's financial activities. The Administrative Assistant will facilitate communication via the appropriate contacts at UCSF such that UC Berkeley can monitor and expedite financial arrangements and also attend to any problems. Project Leaders will receive monthly reports of their financial activities and have ample opportunities to resolve questions and assess the planning of purchases for their research.

Public Health Relevance

The proposed studies will lead to the characterization of a host system of innate immunity that will lead to vaccines and/or therapeutics to treat disease, with relevance to biodefense, emerging infections and global health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI063302-08
Application #
8234235
Study Section
Special Emphasis Panel (ZAI1-QV-I (M3))
Project Start
2011-07-15
Project End
2016-06-30
Budget Start
2011-07-15
Budget End
2012-06-30
Support Year
8
Fiscal Year
2011
Total Cost
$180,029
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Roberts, Allison W; Lee, Bettina L; Deguine, Jacques et al. (2017) Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity 47:913-927.e6
Whiteley, Aaron T; Ruhland, Brittany R; Edrozo, Mauna B et al. (2017) A Redox-Responsive Transcription Factor Is Critical for Pathogenesis and Aerobic Growth of Listeria monocytogenes. Infect Immun 85:
Lobingier, Braden T; Hüttenhain, Ruth; Eichel, Kelsie et al. (2017) An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell 169:350-360.e12
Portman, Jonathan L; Huang, Qiongying; Reniere, Michelle L et al. (2017) Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation. Infect Immun 85:
Fu, Juan; Sen, Rupashree; Masica, David L et al. (2017) Autologous reconstitution of human cancer and immune system in vivo. Oncotarget 8:2053-2068
Barry, Kevin C; Ingolia, Nicholas T; Vance, Russell E (2017) Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. Elife 6:
Tenthorey, Jeannette L; Haloupek, Nicole; López-Blanco, José Ramón et al. (2017) The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science 358:888-893
Deguine, Jacques; Wei, Jessica; Barbalat, Roman et al. (2017) Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production. J Immunol 198:2865-2875
Ekiert, Damian C; Bhabha, Gira; Isom, Georgia L et al. (2017) Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. Cell 169:273-285.e17
Mitchell, Gabriel; Isberg, Ralph R (2017) Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation. Cell Host Microbe 22:166-175

Showing the most recent 10 out of 127 publications