Abstract

The MSGPP Informatics and Data Management Core will assist in maintenance of databases, computers, networks and data integrity for all MSGPP units. This includes installing hardware and software; system administration and computer security; providing storage and tools for data backup and file sharing within MSGPP; maintaining the internal web site for rapid access to shared resources; maintaining the public website and assuring networking for data transfer. A central database will be tightly integrated with local databases to facilitate data transfer and central data storage, enabling MSGPP researchers to track and retrieve data for all the steps done on a target in all MSGPP Projects. This Core will provide tools to mine data to improve the success rate of the units, and help identify bottlenecks in the pipeline and their possiblecauses. This Core will generate the XML information for the TargetDB if NIH to avoid duplication with other structural genomics groups, and for PEPCDB if NIH of protocols for protein production and crystallization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI067921-01
Application #
7071316
Study Section
Special Emphasis Panel (ZAI1-AR-M (S1))
Project Start
2005-09-01
Project End
2009-03-31
Budget Start
2005-09-01
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$252,429
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Pedró-Rosa, Laura; Buckner, Frederick S; Ranade, Ranae M et al. (2015) Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. J Biomol Screen 20:122-30
Koh, Cho Yeow; Kim, Jessica E; Napoli, Alberto J et al. (2013) Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol 189:26-32
Ranade, Ranae M; Gillespie, J Robert; Shibata, Sayaka et al. (2013) Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrob Agents Chemother 57:3021-8
Shibata, Sayaka; Gillespie, J Robert; Ranade, Ranae M et al. (2012) Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem 55:6342-51
Larson, Eric T; Ojo, Kayode K; Murphy, Ryan C et al. (2012) Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem 55:2803-10
Koh, Cho Yeow; Kim, Jessica E; Shibata, Sayaka et al. (2012) Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure 20:1681-91
Zucker, Frank H; Kim, Hae Young; Merritt, Ethan A (2012) PROSPERO: online prediction of crystallographic success from experimental results and sequence. J Appl Crystallogr 45:598-602
Johnson, Steven M; Murphy, Ryan C; Geiger, Jennifer A et al. (2012) Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 55:2416-26
Larson, Eric T; Kim, Jessica E; Napuli, Alberto J et al. (2012) Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr 68:1194-200
Shibata, Sayaka; Zhang, Zhongsheng; Korotkov, Konstantin V et al. (2011) Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem 401:1585-91

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