This POl will depend upon rapid access to both information (to be supplied and utilized by all three of the groups) and materials: especially genetically modified organisms, to be transferred between Osaka and La Jolla. The P01 will also yield information and organisms for use by the entire scientific community. The Administrative Core will oversee and facilitate these transfers: both within the Program and to the rest of the scientific community. It will assure compliance with institutional, national, and international regulations governing material transfer, animal use, and disbursement of funds. It will also coordinate direct interactions between the participating investigators, by means of teleconference, and by means of annual meetings. [This last function of the Administrative Core is perhaps the most crucial. Formal meetings of the consortium guarantee close communication between all of the participating scientists, our Scientific Advisory Board (SAB) members, and program officers of the NIH. We consider that meetings are essential to keep us on a steady and unified course throughout the duration of the grant. Meetings have included, and will continue to include, the participating Pis, members of their laboratories, the SAB, and officers of the NIH. The Administrative Core organizes these meetings and will be responsible for summarizing them. A digest of the principal scientific results disclosed at each meeting, diverse interpretations of these results, and mutual goals will be distributed to the participating laboratories.] The Administrative Core will also oversee and edit a web site, to permit immediate access to data needed within the Program as a whole and by the scientific community at large.

Public Health Relevance

Core A will help to coordinate the entire Program Project Grant, with its strong relevance to human viral infectious disease. The organizational function of Core A will allow for interchange of ideas and data, essential for prosecution of collaborative science. By finding genes and proteins essential for combating viruses and understanding how they work together, the Program Project will realize new advantages in drug design, immunization, and other measures to treat disease.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-EC-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Sw Medical Center Dallas
United States
Zip Code
Kuniyoshi, Kanako; Takeuchi, Osamu; Pandey, Surya et al. (2014) Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A 111:5646-51
Zeng, Ming; Hu, Zeping; Shi, Xiaolei et al. (2014) MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346:1486-92
Lamiable, Olivier; Imler, Jean-Luc (2014) Induced antiviral innate immunity in Drosophila. Curr Opin Microbiol 20:62-8
Majzoub, Karim; Hafirassou, Mohamed Lamine; Meignin, Carine et al. (2014) RACK1 controls IRES-mediated translation of viruses. Cell 159:1086-95
Colak, Elif; Leslie, Alasdair; Zausmer, Kieran et al. (2014) RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. J Immunol 192:5963-73
Lee, Hanna; Komano, Jun; Saitoh, Yasunori et al. (2013) Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A 110:12379-84
Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng et al. (2013) Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge. Proc Natl Acad Sci U S A 110:10717-22
Kemp, Cordula; Mueller, Stefanie; Goto, Akira et al. (2013) Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila. J Immunol 190:650-8
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L et al. (2013) Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A 110:2940-5
Coste, Franck; Kemp, Cordula; Bobezeau, Vanessa et al. (2012) Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster. PLoS One 7:e33416

Showing the most recent 10 out of 47 publications