The Administrative Core of this Program Project is designed to ensure accomplishment of the goals of this multidisciplinary research program. To facilitate this process the Core will oversee budgetary and fiscal aspects of the Program Project, promote and foster interactions among Core and Project investigators, monitor the progress of the Cores and Projects, and act as the central repository for data accumulated over the life of this Program Project. A dedicated Administrative Core is essential to ensure integration and maintain integrity within the University for this inter-institutional program project. The oversight and preparation of budgets as well as reports on fiscal matters will be carried out by the Administrative Core. Further periodic review of the overall scientific progress of this Program Project and the information exchange function of this Core will be achieved by utilizing two complementary mechanisms. First, an Internal Advisory Board comprised of the Core Directors and Project Leaders will meet monthly to review progress, accomplishments and problems in the Cores and Projects. All Project Leaders are on-site. Second, annual reviews of the Program Project will be conducted by members of an External Advisory Panel composed of outside experts in immune regulation and transcription factors. The Administrative Core of this Program Project will provide for budgetary and fiscal oversight of the Program Project as a whole and facilitate the research efforts.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-SV-I)
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University of Pennsylvania
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Akimova, Tatiana; Levine, Matthew H; Beier, Ulf H et al. (2016) Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Methods Mol Biol 1371:43-78
Xiao, Haiyan; Jiao, Jing; Wang, Liqing et al. (2016) HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer 138:2477-86
Levine, Matthew H; Wang, Zhonglin; Xiao, Haiyan et al. (2016) Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int 89:1016-26
Beier, Ulf H; Angelin, Alessia; Akimova, Tatiana et al. (2015) Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. FASEB J 29:2315-26
Chen, Yongheng; Chen, Chunxia; Zhang, Zhe et al. (2015) DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res 43:1268-82
Deng, Guoping; Nagai, Yasuhiro; Xiao, Yan et al. (2015) Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. J Biol Chem 290:20211-20
Wang, Liqing; Liu, Yujie; Han, Rongxiang et al. (2015) FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 125:1111-23
Liu, Yujie; Wang, Liqing; Han, Rongxiang et al. (2014) Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol 34:3993-4007
Akimova, T; Xiao, H; Liu, Y et al. (2014) Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol 7:1209-20
Xiao, Yan; Nagai, Yasuhiro; Deng, Guoping et al. (2014) Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep 7:1471-80

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