The Administrative Core of this Program Project is designed to ensure accomplishment of the goals of this multidisciplinary research program. To facilitate this process the Core will oversee budgetary and fiscal aspects of the Program Project, promote and foster interactions among Core and Project investigators, monitor the progress of the Cores and Projects, and act as the central repository for data accumulated over the life of this Program Project. A dedicated Administrative Core is essential to ensure integration and maintain integrity within the University for this inter-institutional program project. The oversight and preparation of budgets as well as reports on fiscal matters will be carried out by the Administrative Core. Further periodic review of the overall scientific progress of this Program Project and the information exchange function of this Core will be achieved by utilizing two complementary mechanisms. First, an Internal Advisory Board comprised of the Core Directors and Project Leaders will meet monthly to review progress, accomplishments and problems in the Cores and Projects. All Project Leaders are on-site. Second, annual reviews of the Program Project will be conducted by members of an External Advisory Panel composed of outside experts in immune regulation and transcription factors. The Administrative Core of this Program Project will provide for budgetary and fiscal oversight of the Program Project as a whole and facilitate the research efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI073489-05
Application #
8378838
Study Section
Special Emphasis Panel (ZAI1-SV-I)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$48,634
Indirect Cost
$8,641
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Angelin, Alessia; Gil-de-Gómez, Luis; Dahiya, Satinder et al. (2017) Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab 25:1282-1293.e7
Gerriets, Valerie A; Kishton, Rigel J; Johnson, Marc O et al. (2016) Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol 17:1459-1466
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Xiao, Haiyan; Jiao, Jing; Wang, Liqing et al. (2016) HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer 138:2477-86
Akimova, Tatiana; Levine, Matthew H; Beier, Ulf H et al. (2016) Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Methods Mol Biol 1371:43-78
Chen, Yongheng; Chen, Chunxia; Zhang, Zhe et al. (2015) DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res 43:1268-82
Deng, Guoping; Nagai, Yasuhiro; Xiao, Yan et al. (2015) Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. J Biol Chem 290:20211-20
Beier, Ulf H; Angelin, Alessia; Akimova, Tatiana et al. (2015) Essential role of mitochondrial energy metabolism in Foxp3? T-regulatory cell function and allograft survival. FASEB J 29:2315-26
Wang, Liqing; Liu, Yujie; Han, Rongxiang et al. (2015) FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 125:1111-23

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