Abstract

The Core will primarily be used as a shared facility for the production of various transgenic and knockout (knock in) animals for the investigators of the proposed program project. In addition to this, the Core provides a broad range of animal related services to maximize the efficiency of each project and enhance interactions among the investigators. The Core has more than 15 years of history of assisting investigators on the Penn campus as well as in foreign countries and contributed to numerous collaborative works that were published in leading scientific journals. The Core aims to play a pivotal role in the Program Project for assuring integrity of the experimental data by providing genetically defined experimental animals as well as materials and information for production and analysis of those animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI073489-05
Application #
8378839
Study Section
Special Emphasis Panel (ZAI1-SV-I)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$175,149
Indirect Cost
$31,119

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Jiao, Jing; Han, Rongxiang; Hancock, Wayne W et al. (2017) Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells. Methods Mol Biol 1510:287-293
Huang, Jianbing; Wang, Liqing; Dahiya, Satinder et al. (2017) Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep 7:8626
Angelin, Alessia; Gil-de-Gómez, Luis; Dahiya, Satinder et al. (2017) Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab 25:1282-1293.e7
Gerriets, Valerie A; Kishton, Rigel J; Johnson, Marc O et al. (2016) Foxp3 and Toll-like receptor signaling balance Tregcell anabolic metabolism for suppression. Nat Immunol 17:1459-1466
Akimova, Tatiana; Levine, Matthew H; Beier, Ulf H et al. (2016) Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Methods Mol Biol 1371:43-78
Xiao, Haiyan; Jiao, Jing; Wang, Liqing et al. (2016) HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer 138:2477-86
Levine, Matthew H; Wang, Zhonglin; Xiao, Haiyan et al. (2016) Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int 89:1016-1026
Chen, Yongheng; Chen, Chunxia; Zhang, Zhe et al. (2015) DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res 43:1268-82
Deng, Guoping; Nagai, Yasuhiro; Xiao, Yan et al. (2015) Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. J Biol Chem 290:20211-20
Beier, Ulf H; Angelin, Alessia; Akimova, Tatiana et al. (2015) Essential role of mitochondrial energy metabolism in Foxp3? T-regulatory cell function and allograft survival. FASEB J 29:2315-26

Showing the most recent 10 out of 38 publications