The Administrative Core will provide the organizational management to assure that the program project: """"""""Characterization of Immunogenic and Structural properties of HIV-1 Envelope"""""""" meets its objectives effectively.
The aims are:
Aim 1. To establish an organizational structure that assures effective scientific leadership. Dr. Karn's main objective as a leader of the Administrative Core is to remove the administrative and organizational burden from Dr. Cho, the P.I., so that he can focus his energy entirely on running the scientific aspects of the program.
Aim 2. To establish and maintain an infrastructure to support the fiscal monitoring and reporting requirements of the project. A critical role of the Administrative Core will be to provide strong financial and administrative management of the program. This goal will be accomplished through the efforts of an outstanding administrative team comprised of a Program Manager, a Financial Administrator, and an Administrative Assistant.
Aim 3. To establish and maintain a system to promote scientific interchange and collaboration, and to enhance sharing of access to resources and research output among team members and with the scientific community. A major goal of the Administrative Core is to enhance scientific interchange and collaboration among investigators with the goal of rapidly developing new vaccine products that meet scientific objectives of novelty and the practical objectives of efficacy, ease of manufacture and delivery. To ensure sharing of resources and research output, the Core will be responsible for creating and maintaining a consortium website as well as scheduling regular meetings of the participants.
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|Qin, Yali; Banerjee, Saikat; Agrawal, Aditi et al. (2015) Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop. PLoS One 10:e0128823|
|Habte, Habtom H; Banerjee, Saikat; Shi, Heliang et al. (2015) Immunogenic properties of a trimeric gp41-based immunogen containing an exposed membrane-proximal external region. Virology 486:187-97|
|Qin, Yali; Shi, Heliang; Banerjee, Saikat et al. (2014) Detailed characterization of antibody responses against HIV-1 group M consensus gp120 in rabbits. Retrovirology 11:125|
|Qin, Yali; Banasik, Marisa; Kim, SoonJeung et al. (2014) Eliciting neutralizing antibodies with gp120 outer domain constructs based on M-group consensus sequence. Virology 462-463:363-76|
|Hioe, Catarina E; Tuen, Michael; Vasiliver-Shamis, Gaia et al. (2011) HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PLoS One 6:e23202|
|Shi, Wuxian; Bohon, Jen; Han, Dong P et al. (2010) Structural characterization of HIV gp41 with the membrane-proximal external region. J Biol Chem 285:24290-8|
|Wang, Liwen; Qin, Yali; Ilchenko, Serguei et al. (2010) Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometry. Biochemistry 49:9032-45|