The Clinical Core is organized to provide the clinical samples for all 4 projects. The core will have 4functions: 1) to recruit and amange patients for the 3 protocols supporting the 4 projects, 2) to collect,process and catalogue all tissues (blood, lymph node, and GALT), 3) to assist the Administrative Core withtissue shipping and management of regulatory issues related to protocol administration, and 4) to maintainall patient and clinical laboratory records in a case report form and enter data into the established data base.Patients will be followed in the NIH funded General Clinical Research Center where all blood will be drawnand patients will receive required pre and post operative care. Tissues will receive initial processing throughthe clinical core and appropriate samples will be packed and shipped to off-site investigators. In addition, allclinical information (status, medications, clinical laboratory measures like CD4 and HIV viral load) will bemaintained in a patient chart and entered into a central database by the nurse manager. Over the course ofthese projects we will recruit 70 individuals into 3 protocols that require lymph node and colon biopsy. Wepresent data to show this goal is within the scope of recent accomplishments by our group. Protocol A willsupport Hypothesis 1 and distribute tissues to investigators in Projects 1, 2, and 4. Protocol B will supportHypothesis 2 and will distribute tissues to investigators in all 4 projects, and Protocol C will supportHypothesis 3 and distribute tissues to investigators in Projects 1, 2, and 4.
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