The Administrative Core will provide the scientific leadership and organizational management to assure that the program project: """"""""Defining the Pathogenesis of immune deficiency in chronic HIV infection"""""""" meets its objectives effectively by: Developing an organizational structure that assures effective scientific leadership. Providing the fiscal and administrative management of the program, including grant reporting requirements, accounting and sub-contracts that includes coordination of communications with NIH and with industry collaborators and assuring seamless coordination of access to resources within the program to assure their timely and cost-efficient utilization to assist in project completion. Coordinating communication among all project investigators, project Cores and institutional administrations located at multiple institutions and among program external advisors. This will include organizing team meetings, conference calls and recording and distributing minutes of calls and distribution of presentations. Maintaining a system to promote sharing of research output of the group that includes maintaining a web site for Project documents, methods, manuscripts, publications, slide presentations and other key information on program progress. Monitoring scientific productivity, assuring appropriate resource allocation and establishing a mechanism for resolution of any conflicts should they arise.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-PRJ-A)
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Case Western Reserve University
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Luo, Zhenwu; Ma, Lei; Zhang, Lumin et al. (2016) Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination. Vaccine 34:1945-55
Shive, Carey L; Clagett, Brian; McCausland, Marie R et al. (2016) Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection. J Acquir Immune Defic Syndr 71:483-92
Panigrahi, Soumya; Freeman, Michael L; Funderburg, Nicholas T et al. (2016) SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction. J Infect Dis 213:1419-27
McGinty, Tara; Mirmonsef, Paria; Mallon, Patrick W G et al. (2016) Does systemic inflammation and immune activation contribute to fracture risk in HIV? Curr Opin HIV AIDS 11:253-60
Siedner, Mark J; Kim, June-Ho; Nakku, Ruth Sentongo et al. (2016) HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS 30:667-70
Pandiyan, Pushpa; Younes, Souheil-Antoine; Ribeiro, Susan Pereira et al. (2016) Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation. Front Immunol 7:228
Siedner, Mark J; Kim, June-Ho; Nakku, Ruth Sentongo et al. (2016) Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy. J Infect Dis 213:370-8
Fu, P; Hughes, J; Zeng, G et al. (2016) A comparative investigation of methods for longitudinal data with limits of detection through a case study. Stat Methods Med Res 25:153-66
Mudd, Joseph C; Panigrahi, Soumya; Kyi, Benjamin et al. (2016) Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions. J Infect Dis 214:1808-1816
Lee, Sulggi A; Mefford, Joel A; Huang, Yong et al. (2016) Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS 30:1807-15

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